Dimethylformamide [MAK Value Documentation, 1997]

doi:10.1002/3527600418.mb6812e0008

The MAK‐Collection for Occupational Health and Safety 2012

DOI: 10.1002/3527600418.mb6812e0008

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Dimethylformamide [MAK Value Documentation, 1997]

Abstract: Published in the series Occupational Toxicants , Vol. 8 (1997) The article contains sections titled: Toxic Effects and Modes of Action Pharmacokinetics Effects in Man Effects on Animals Acute and subacute toxicity Subchronic and chronic toxicity … Show more

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3‐Methyl‐5‐isopropylhydantoin as hemoglobin adduct of N,N‐dimethylformamide and methylisocyanate [Biomonitoring Methods, 2015]

Käfferlein¹,

Angerer²,

Leng³

et al. 2016

The MAK‐Collection for Occupational Health and Safety

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The analytical method describes the specific determination of 3‐methyl‐5‐isopropylhydantoin (MIH), a hemoglobin adduct of N,N‐dimethylformamide. Following addition of 13 C 5 , 15 N‐3‐methyl‐5‐isopropylhydantoin ( 13 C 5 , 15 N‐MIH) as internal standard, isolated globin is subjected to acid hydrolysis for one hour at 110°C. After pH adjustment (pH 3 – 5) the hydrolysate is extracted twice with ethyl acetate. The combined extracts are washed with sodium hydrogen carbonate solution and dried under a stream of nitrogen. The residue is dissolved in ethyl acetate. An aliquot of the solution is analyzed using GC–MS. For calibration purposes, calibration standards are prepared in pooled globin. They are processed in the same way as the samples to be analyzed.

show abstract

3‐Methyl‐5‐isopropylhydantoin as hemoglobin adduct of N,N‐dimethylformamide and methylisocyanate [Biomonitoring Methods, 2015]

Käfferlein¹,

Angerer²,

Leng³

et al. 2016

The MAK‐Collection for Occupational Health and Safety

View full text Add to dashboard Cite

show abstract

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Dimethylformamide [MAK Value Documentation, 1997]

Abstract: Published in the series Occupational Toxicants , Vol. 8 (1997) The article contains sections titled: Toxic Effects and Modes of Action Pharmacokinetics Effects in Man Effects on Animals Acute and subacute toxicity Subchronic and chronic toxicity … Show more

Cited by 1 publication

References 72 publications

3‐Methyl‐5‐isopropylhydantoin as hemoglobin adduct of N,N‐dimethylformamide and methylisocyanate [Biomonitoring Methods, 2015]

3‐Methyl‐5‐isopropylhydantoin as hemoglobin adduct of N,N‐dimethylformamide and methylisocyanate [Biomonitoring Methods, 2015]

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