Diminished frontal pole size and functional connectivity in young adults with high suicidality

Kim, Gwang-Won; Farabaugh, Amy; Vetterman, Richard; Holmes, Avram J.; Nyer, Maren; Nasiriavanaki, Zahra; Fava, Maurizio; Holt, Daphne J.

doi:10.1016/j.jad.2022.04.069

Cited by 13 publications

(17 citation statements)

References 72 publications

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“…Thalamic subnuclei were calculated using FreeSurfer 7.2 software package. Resting-state fMRI data analysis included runs with a temporal signal-to-noise ratio greater than 125 and a relative head motion value of less than 1 mm between one or more pairs of consecutive TRs [ 30 ].…”

Section: Methodsmentioning

confidence: 99%

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Altered brain morphology and functional connectivity in postmenopausal women: automatic segmentation of whole-brain and thalamic subnuclei and resting-state fMRI

Kim,

Park,

Kim

et al. 2024

Aging

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The transition to menopause is associated with various physiological changes, including alterations in brain structure and function. However, menopause-related structural and functional changes are poorly understood. The purpose of this study was not only to compare the brain volume changes between premenopausal and postmenopausal women, but also to evaluate the functional connectivity between the targeted brain regions associated with structural atrophy in postmenopausal women. Each 21 premenopausal and postmenopausal women underwent magnetic resonance imaging (MRI). T1-weighted MRI and resting-state functional MRI data were used to compare the brain volume and seed-based functional connectivity, respectively. In statistical analysis, multivariate analysis of variance, with age and whole brain volume as covariates, was used to evaluate surface areas and subcortical volumes between the two groups. Postmenopausal women showed significantly smaller cortical surface, especially in the left medial orbitofrontal cortex (mOFC), right superior temporal cortex, and right lateral orbitofrontal cortex, compared to premenopausal women ( p < 0.05, Bonferroni-corrected) as well as significantly decreased functional connectivity between the left mOFC and the right thalamus was observed ( p < 0.005, Monte-Carlo corrected). Although postmenopausal women did not show volume atrophy in the right thalamus, the volume of the right pulvinar anterior, which is one of the distinguished thalamic subnuclei, was significantly decreased ( p < 0.05, Bonferroni-corrected). Taken together, our findings suggest that diminished brain volume and functional connectivity may be linked to menopause-related symptoms caused by the lower sex hormone levels.

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Section: Methodsmentioning

confidence: 99%

“…T1-weighted images were analyzed with the procedure described in our previous studies [ 30 , 31 ]. We incorporated advanced motion correction techniques and intensity non-uniformity adjustments.…”

Section: Methodsmentioning

confidence: 99%

Altered brain morphology and functional connectivity in postmenopausal women: automatic segmentation of whole-brain and thalamic subnuclei and resting-state fMRI

Kim,

Park,

Kim

et al. 2024

Aging

Self Cite

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“…In addition, two phases of dummy scans were supplemented to circumvent unstable fMRI signals. The Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) protocol was used for outlier detection and visual inspection [30,31].…”

Section: Subjectsmentioning

confidence: 99%

“…Anatomical and functional MR images were analyzed using Statistical Parametric Mapping (SPM8, Wellcome Department of Cognitive Neurology, University College London, London, UK). The Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) protocol was used for outlier detection and visual inspection [30,31,34]. In the fMRI data, the analyses included a head motion value of < 2 mm.…”

Section: Mri Processing and Analysismentioning

confidence: 99%

Dissociation between cognition and emotion regulation in patients with post-traumatic stress disorder: A combined gray matter volume and a delayed-response working memory task

Kim¹,

Park²,

Yang³

2023

Preprint

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Post-traumatic stress disorder (PTSD) has been associated with cognitive and emotional dysregulation for inhibitory control, yet currently, there are no validated methods for dissociation between cognition and emotion regulation in patients with PTSD. Thus, this study evaluated the differential brain activation patterns associated with cognitive and emotional distractors during working memory (WM) maintenance for human faces between patients with PTSD and healthy controls (HCs) and assessed the relationship between changes in the activation patterns by the opposing effects of distraction types and gray matter volume (GMV). Twenty-four patients with PTSD and 24 HCs underwent T1-weighted magnetic resonance imaging (MRI) and event-related functional MRI (fMRI). PTSD symptoms were evaluated using the Clinically Administered PTSD Scale. Event-related fMRI data were recorded while subjects performed a delayed-response WM task with human face and trauma-related distractors. Compared to the HCs, the patients with PTSD showed significantly reduced GMV of the inferior frontal gyrus (IFG) and significantly higher GMV of the inferior temporal gyrus (p < 0.05). In the delayed-response WM tasks, the patients showed significantly increased activities in the superior temporal gyrus (STG) and middle temporal gyrus compared with HCs during a maintenance trial (p < 0.05). For the human face distractor trial, the patients showed significantly decreased activities in the superior frontal gyrus and IFG compared with HCs (p < 0.05). In addition, the patients showed lower scores and slower reaction times for the face recognition task with trauma-related distractors compared with HCs and showed significantly increased activities in the middle frontal gyrus and STG during the trauma-related distractor trial (p < 0.05). Differential brain activation patterns associated with the effects of distraction in PTSD patients may be linked to neural mechanisms with impairments in cognitive control for confusable distractors and in the ability to control emotional distraction.

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“…A reduced clustering coefficient implies that the anterior cingulate will be less able to access such regulatory resources as would usually be supplied by the frontal poles. The consequences of this could be significant: frontal pole structural measures are negatively correlated with impulsivity (Merz et al, 2018) and suicidality (Kim et al, 2022) within adolescent populations, highlighting the impact dysfunction involving this region can have on important clinical outcomes.…”

Section: Topological Brain Network Properties Of State Irritabilitymentioning

confidence: 99%

Exploring static and dynamic functional brain networks in adolescent depression using a co-produced novel irritability paradigm

MacSweeney,

Cabral,

Stolicyn

et al. 2023

Preprint

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Irritability is a core symptom of depression in adolescence and a risk factor for emotion regulation problems. However, its neural correlates are not well understood. Existing fMRI research on irritability typically overlooks its social context. Here, we pilot a novel naturalistic fMRI paradigm targeting the social nature of irritability that was co-produced with young people and apply it in an independent sample of youth (N = 29, mean age 18.9 years, 77% female) with self-reported low mood. We first investigated whether graph theoretic and dynamical properties of functional brain networks differed between a resting state scan and our irritability paradigm before examining whether these brain features were associated with depressive symptoms and trait irritability. Using Leading Eigenvector Dynamics Analysis (LEiDA), we found that the dynamic properties of brain networks comprising default-mode and fronto-parietal regions differed significantly during the irritability paradigm compared to the rest condition. While no gross static topological differences were found between these two conditions, we found that some dynamic and topological features of emotion-related brain networks were related to trait irritability and depressive symptoms in our sample. Although the current findings are preliminary due to the pilot nature of this study, this work showcases the feasibility of co-produced research in neuroimaging and lays a strong foundation for further study.

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Diminished frontal pole size and functional connectivity in young adults with high suicidality

Cited by 13 publications

References 72 publications

Altered brain morphology and functional connectivity in postmenopausal women: automatic segmentation of whole-brain and thalamic subnuclei and resting-state fMRI

Altered brain morphology and functional connectivity in postmenopausal women: automatic segmentation of whole-brain and thalamic subnuclei and resting-state fMRI

Dissociation between cognition and emotion regulation in patients with post-traumatic stress disorder: A combined gray matter volume and a delayed-response working memory task

Exploring static and dynamic functional brain networks in adolescent depression using a co-produced novel irritability paradigm

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