Diminished pheromone‐induced sexual behavior in neurokinin‐1 receptor deficient (TACR1<sup>−/−</sup>) mice

Berger, Alexandra; Tran, Anne H.; Dida, Joana; Minkin, Salomon; Gerard, Norma P.; Yeomans, John S.; Paige, Christopher J.

doi:10.1111/j.1601-183x.2012.00787.x

Cited by 21 publications

(13 citation statements)

References 35 publications

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“…The task elicits sexually motivated hedonic behaviour that has been shown to be impaired following a chronic restraint stress model of depression in mice, as well as respond to chronic citalopram in a learned helplessness model of depression (Finger et al, 2011;Malkesman et al, 2010). The FUST has also been used to evaluate the role of proteins such as the neurokinin-1 receptor in depressive-like behaviours in mice (Berger et al, 2012). In addition, a 21-day chronic stress model of depression in rats has previously been shown to reduce sexual behaviours in male rats (Bhattacharya and Muruganandam, 2003).…”

Section: Discussionmentioning

confidence: 99%

Repeated daily administration of increasing doses of lipopolysaccharide provides a model of sustained inflammation-induced depressive-like behaviour in mice that is independent of the NLRP3 inflammasome

Wickens

Donck

Mackenzie

et al. 2018

Behavioural Brain Research

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Mounting preclinical evidence has implicated the NLRP3 inflammasome in depression-related behaviours elicited by chronic stress or acute lipopolysaccharide (LPS) challenge. However, the relevance of acute LPS as a model of depression has been questioned and behavioural time-courses of its effects can be inconsistent. The aims of this study were (1) to develop a novel protocol for repeated daily LPS administration and (2) to use this model to assess the involvement of NLRP3 inflammasome signalling in sustained inflammation-induced depressive-like behaviour in adult C57BL/6J mice deficient in NLRP3. Acute LPS (0.83mg/kg; i.p.) induced sickness behaviour evident as hypolocomotor activity. However, there was no significant increase in depressive-like behaviour in the forced swim test 24h post-administration. Interestingly, depressive-like behaviours were observed in the female urine sniffing test and in the sucrose preference test at 24h, but not 48h, post-administration of acute LPS. To mimic a period of sustained inflammation, 3-day repeated increasing LPS doses (0.1, 0.42 and 0.83mg/kg; i.p.) was compared to constant LPS doses (0.83mg/kg; i.p.). Sickness behaviour was seen in response to increasing doses, but tolerance developed to repeated constant doses of LPS. Furthermore, 3-day increasing doses of LPS resulted in a significant increase in immobility time in the forced swim test, consistent with depressive-like behaviour. When NLRP3 mice received this 3-day increasing dose regimen of LPS, sickness behaviours were attenuated compared to wild-type mice. The behaviour in the forced swim test was not significantly altered in NLRP3 mice. We propose that this increasing repeated dosing LPS model of inflammation-induced depressive-like behaviour may better model the sustained inflammation observed in depression and may provide a more translationally relevant paradigm to study the inflammatory mechanisms that contribute to depression.

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Section: Discussionmentioning

confidence: 99%

Repeated daily administration of increasing doses of lipopolysaccharide provides a model of sustained inflammation-induced depressive-like behaviour in mice that is independent of the NLRP3 inflammasome

Wickens

Donck

Mackenzie

et al. 2018

Behavioural Brain Research

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“…Solvents such as pentane, dichloromethane, hexane, and ethyl ether are extensively used in pheromone extraction because of their high volatility-using a volatile solvent allows the extracts to be concentrated at relatively low temperatures [48,49].…”

Section: Analytical Methods Employed To Obtain Pheromone Moleculesmentioning

confidence: 99%

Tools for detecting insect semiochemicals: a review

et al. 2018

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Semiochemicals are chemical compounds that are released by many species as a means of intra- and interspecific communication. Insects have extremely advanced olfactory systems; indeed, they rely on smell when performing many of their main behaviors, such as oviposition, breeding, prey location, and defense. This characteristic of insects implies that semiochemicals could be used for various applications, including in agriculture, where they could be employed along with other tools to control pest insects. The aim of this review is to present the main techniques used and the state of the art in the detection of semiochemicals, focusing on pheromones. In addition to the traditional methods of identifying semiochemicals, such as gas chromatography coupled to a high-resolution detection mode (e.g., flame ionization (FID), electron capture (ECD), photoionization (PID), or mass spectrometry (MS)), other tools are addressed in this review, including sensors and biosensors. While these new technologies may be used under laboratory conditions to improve or complement technologies that are already being used, they are mainly intended for use as new agricultural tools for detecting and controlling pest insects in the field.

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“…Tac1 −/− and Tacr1 −/− mice were generated at the University of Liverpool as previously described [26], [27], [28], [29]. Tac4 −/− and Tac1 −/−/ Tac4 −/− mice were obtained from Berger et al [30], [31]. The animals were bred and kept in the Laboratory Animal House of the Department of Pharmacology and Pharmacotherapy of the University of Pécs at 24–25°C, provided with standard mouse chow and water ad libitum and maintained under a 12-h light-dark cycle.…”

Section: Methodsmentioning

confidence: 99%

Role of Tachykinin 1 and 4 Gene-Derived Neuropeptides and the Neurokinin 1 Receptor in Adjuvant-Induced Chronic Arthritis of the Mouse

et al. 2013

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ObjectiveSubstance P, encoded by the Tac1 gene, is involved in neurogenic inflammation and hyperalgesia via neurokinin 1 (NK1) receptor activation. Its non-neuronal counterpart, hemokinin-1, which is derived from the Tac4 gene, is also a potent NK1 agonist. Although hemokinin-1 has been described as a tachykinin of distinct origin and function compared to SP, its role in inflammatory and pain processes has not yet been elucidated in such detail. In this study, we analysed the involvement of tachykinins derived from the Tac1 and Tac4 genes, as well as the NK1 receptor in chronic arthritis of the mouse.MethodsComplete Freund’s Adjuvant was injected intraplantarly and into the tail of Tac1−/−, Tac4−/−, Tacr1−/− (NK1 receptor deficient) and Tac1−/−/Tac4−/− mice. Paw volume was measured by plethysmometry and mechanosensitivity using dynamic plantar aesthesiometry over a time period of 21 days. Semiquantitative histopathological scoring and ELISA measurement of IL-1β concentrations of the tibiotarsal joints were performed.ResultsMechanical hyperalgesia was significantly reduced from day 11 in Tac4−/− and Tacr1−/− animals, while paw swelling was not altered in any strain. Inflammatory histopathological alterations (synovial swelling, leukocyte infiltration, cartilage destruction, bone damage) and IL-1β concentration in the joint homogenates were significantly smaller in Tac4−/− and Tac1−/−/Tac4−/− mice.ConclusionsHemokinin-1, but not substance P increases inflammation and hyperalgesia in the late phase of adjuvant-induced arthritis. While NK1 receptors mediate its antihyperalgesic actions, the involvement of another receptor in histopathological changes and IL-1β production is suggested.

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Diminished pheromone‐induced sexual behavior in neurokinin‐1 receptor deficient (TACR1^−/−) mice

Cited by 21 publications

References 35 publications

Repeated daily administration of increasing doses of lipopolysaccharide provides a model of sustained inflammation-induced depressive-like behaviour in mice that is independent of the NLRP3 inflammasome

Repeated daily administration of increasing doses of lipopolysaccharide provides a model of sustained inflammation-induced depressive-like behaviour in mice that is independent of the NLRP3 inflammasome

Tools for detecting insect semiochemicals: a review

Role of Tachykinin 1 and 4 Gene-Derived Neuropeptides and the Neurokinin 1 Receptor in Adjuvant-Induced Chronic Arthritis of the Mouse

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Diminished pheromone‐induced sexual behavior in neurokinin‐1 receptor deficient (TACR1−/−) mice

Cited by 21 publications

References 35 publications

Repeated daily administration of increasing doses of lipopolysaccharide provides a model of sustained inflammation-induced depressive-like behaviour in mice that is independent of the NLRP3 inflammasome

Repeated daily administration of increasing doses of lipopolysaccharide provides a model of sustained inflammation-induced depressive-like behaviour in mice that is independent of the NLRP3 inflammasome

Tools for detecting insect semiochemicals: a review

Role of Tachykinin 1 and 4 Gene-Derived Neuropeptides and the Neurokinin 1 Receptor in Adjuvant-Induced Chronic Arthritis of the Mouse

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Diminished pheromone‐induced sexual behavior in neurokinin‐1 receptor deficient (TACR1^−/−) mice