Diminished rostral anterior cingulate activity in response to threat-related events in posttraumatic stress disorder

Kim, M. Justin; Chey, Jeanyung; Chung, Ain; Bae, Sohyun; Khang, Hyunsoo; Ham, Byung Joo; Yoon, Sujung; Jeong, Do Un; Lyoo, In Kyoon

doi:10.1016/j.jpsychires.2007.02.003

Cited by 82 publications

(65 citation statements)

References 26 publications

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“…N. Zhang et al, 2013) (Astur et al, 2006;Aupperle et al, 2012;Bluhm et al, 2012;Bruce et al, 2013;Bryant et al, 2005;Bryant et al, 2008;El Khoury-Malhame et al, 2011;Elman et al, 2009; A c c e p t e d M a n u s c r i p t Falconer et al, 2008;Felmingham et al, 2010;Felmingham et al, 2009;Fonzo et al, 2010;Frewen et al, 2010;Frewen et al, 2012;Jatzko, Schmitt, Demirakca, Weimer, & Braus, 2006;Kim et al, 2008;Landré et al, 2012;Mazza et al, 2012;Mazza et al, 2013;Protopopescu, Pan, Tuescher, Cloitre, Goldstein, Engelien, Epstein, Yang, Gorman, LeDoux, et al, 2005;Sailer et al, 2008;Sakamoto et al, 2005;Schechter et al, 2012;Simmons et al, 2008;Simmons, Strigo, Matthews, Paulus, & Stein, 2009;Steuwe et al, 2014;Strigo et al, 2010;Thomaes et al, 2009;van Rooij et al, 2014;Werner et al, 2009;Williams et al, 2006;Zhang et al, 2013). Due to overlap between participants used in multiple studies, one study was excluded from each group, leaving the final meta-analysis of trauma-exposed controls compared to individuals with PTSD comprised of 1718 studies (521577 participants, 144145 foci) for whole-brain analyses; and 20 studies (609 participants, 93 foci) for ROI analyses.…”

Section: Part 3: Ptsd Vs Trauma-naïve Controlsmentioning

confidence: 99%

Post-traumatic stress influences the brain even in the absence of symptoms: A systematic, quantitative meta-analysis of neuroimaging studies

Stark¹,

Parsons²,

Hartevelt³

et al. 2015

Neuroscience & Biobehavioral Reviews

138

104

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Section: Part 3: Ptsd Vs Trauma-naïve Controlsmentioning

confidence: 99%

Post-traumatic stress influences the brain even in the absence of symptoms: A systematic, quantitative meta-analysis of neuroimaging studies

Stark¹,

Parsons²,

Hartevelt³

et al. 2015

Neuroscience & Biobehavioral Reviews

138

104

View full text Add to dashboard Cite

“…The majority of functional MRI studies in PTSD have presented emotional stimuli or used a symptom provocation design (e.g., Rauch et al, 1996;Bremner et al, 1999;Kim et al, 2008). More relevant to the present study are fMRI experiments that presented nonemotional stimuli in cognitive control tasks.…”

Section: Anterior Cingulate Cortex and Ptsdmentioning

confidence: 99%

Intact error monitoring in combat Veterans with post-traumatic stress disorder

Swick

Honzel

Turken

2015

Psychiatry Research: Neuroimaging

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The error-related negativity (ERN) is a neuroelectric signature of performance monitoring during speeded response time tasks. Previous studies indicate that individuals with anxiety disorders show ERN enhancements that correlate with the degree of clinical symptomology. Less is known about the error monitoring system in post-traumatic stress disorder (PTSD). PTSD is characterized by impairments in the regulation of fear and other emotional responses, as well as deficits in maintaining cognitive control. Here, combat Veterans with PTSD were compared to control Veterans in two different versions of the flanker task (n=13 or 14 per group). Replicating and extending previous findings, PTSD patients showed an intact ERN in both experiments. In addition, task performance and error compensation behavior were intact. Finally, ERN amplitude showed no relationship with self-reported PTSD, depression, or post-concussive symptoms. These results suggest that error monitoring represents a relative strength in PTSD that can dissociate from cognitive control functions that are impaired, such as response inhibition and sustained attention. A healthy awareness of errors in external actions could be leveraged to improve interoceptive awareness of emotional state. The results could have positive implications for PTSD treatments that rely on self-monitoring abilities, such as neurofeedback and mindfulness training.

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“…Such diminished activation has occurred during the recollection of personal traumatic-events (Bremner, Narayan, et al, 1999;Britton, Phan, Taylor, Fig, & Liberzon, 2005;Lanius et al, 2001;Lindauer et al, 2004;Shin et al, 1999;, in response to both trauma-related stimuli Bremner et al, 2004;Hou et al, 2007) and trauma-unrelated emotional stimuli (Kim et al, 2007;Phan, Britton, Taylor, Fig, & Liberzon, 2006;Shin et al, 2005;Williams et al, 2006), as well as during neutral tasks or at rest (Molina, Isoardi, Prado, & Bentolila, 2007;Semple et al, 2000). In addition, medial prefrontal activation is negatively correlated with PTSD symptom severity (Britton et al, 2005;Dickie et al, 2008;Hopper, Frewen, van der Kolk, & Lanius, 2007;Kim et al, 2007;Shin et al, 2005). Finally, successful treatment has been associated with increased activation in medial prefrontal cortex (Felmingham et al, 2007;Lansing, Amen, Hanks, & Rudy, 2005;Peres et al, 2007;Seedat et al, 2004) (but see also .…”

Section: Medial Prefrontal Cortexmentioning

confidence: 99%

Is posttraumatic stress disorder a stress‐induced fear circuitry disorder?

Shin

Handwerger

2009

Journal of Traumatic Stress

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Neuroimaging studies of posttraumatic stress disorder (PTSD) have reported functional abnormalities in brain regions involved in fear conditioning, extinction, and emotion regulation. These findings have prompted researchers to consider whether PTSD can be characterized as a stress-induced fear circuitry disorder. In this review, the authors summarize the results of functional neuroimaging studies and conclude that there is a strong argument for characterizing PTSD as a stress-induced fear circuitry disorder. They also acknowledge that (a) fear is not the only emotion associated with PTSD, (b) a state of fear is not required to observe fear-circuitry abnormalities in this disorder, and (c) not all functional abnormalities in PTSD are related to fear circuitry. Implications for future diagnostic classifications are discussed.

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Diminished rostral anterior cingulate activity in response to threat-related events in posttraumatic stress disorder

Cited by 82 publications

References 26 publications

Post-traumatic stress influences the brain even in the absence of symptoms: A systematic, quantitative meta-analysis of neuroimaging studies

Post-traumatic stress influences the brain even in the absence of symptoms: A systematic, quantitative meta-analysis of neuroimaging studies

Intact error monitoring in combat Veterans with post-traumatic stress disorder

Is posttraumatic stress disorder a stress‐induced fear circuitry disorder?

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