Dioscin: Therapeutic potential for diabetes and complications

Gao, Haoyang; Wang, Ze; Zhu, Danlin; Zhao, Linlin; Xiao, Weihua

doi:10.1016/j.biopha.2023.116051

Cited by 8 publications

(2 citation statements)

References 126 publications

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“…Diabetes is a complex physiological condition characterized by disrupted insulin production and utilization, leading to elevated blood glucose levels [1][2][3]. It is categorized into two primary types: Type 1 and Type 2 [4,5].…”

Section: Introductionmentioning

confidence: 99%

Optimizing Blood Glucose Regulation in Type 1 Diabetes Patients via Genetic Algorithm-Based Fuzzy Logic Controller Considering Substantial Meal Protocol

Ndakara Abubakar,

Essabbar,

Saikouk

2024

Int. J. Onl. Eng.

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Effective management of blood glucose levels in individuals with type 1 diabetes, especially after meals, is crucial for diabetes care. Artificial pancreas systems (APS) perform automated insulin delivery in subjects with type 1 diabetes mellitus (T1DM). In this study, an optimized fuzzy logic controller was designed to achieve a euglycemic range after a substantial meal intake. All in silico simulations were performed using the MATLAB/Simulink environment, leveraging control variability grid analysis (CVGA), and the performance of the controller was evaluated. The proposed controller is based on a fuzzy-logic control law designed in three stages. First, a nonlinear framework of the glucose-insulin regulatory system was identified based on the heavy meal protocol of three patients given as follows: for subject ID 117-1, a total of 295 gCHO; for subject ID 126-1, 236 gCHO; and subject ID 128-1, 394 gCHO over a day. Then, an iterative tree structure was employed to establish a stabilizing control rule for insulin delivery, integrating inputs from two Mamdani Fuzzy Inference System (FIS) objects. Finally, a genetic algorithm refines the control system by fine-tuning the uncertainty of the fuzzy membership functions. Two scenarios were considered for three patients to assess the performance of the proposed controller. The results indicated its effectiveness under various conditions, achieving a time in the range of 61.25%, 71% and 61.10% respectively for the three subjects. The obtained results are analyzed and compared with IMC and multi-objective output feedback controllers. The findings of the study reveal that the proposed controller shows promising advancements in tailored strategies for type 1 diabetes patients, outperforming the other controllers in terms of blood glucose regulation.

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Section: Introductionmentioning

confidence: 99%

Optimizing Blood Glucose Regulation in Type 1 Diabetes Patients via Genetic Algorithm-Based Fuzzy Logic Controller Considering Substantial Meal Protocol

Ndakara Abubakar,

Essabbar,

Saikouk

2024

Int. J. Onl. Eng.

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“…The volume can vary from about 72 µm 3 in hypertonic to about 150 µm 3 in hypotonic conditions. These changes in erythrocyte volume, and at a constant hemoglobin volume of 23 µm 3 , also lead to a change in the refractive index of the RBCs and in the intensity of the scattered light [11,12].…”

Section: Introductionmentioning

confidence: 99%

Change in Osmotic Pressure Influences the Absorption Spectrum of Hemoglobin inside Red Blood Cells

Karabaliev,

Tacheva,

Paarvanova

et al. 2024

Cells

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Absorption spectra of red blood cell (RBC) suspensions are investigated in an osmolarity range in the medium from 200 mOsm to 900 mOsm. Three spectral parameters are used to characterize the process of swelling or shrinkage of RBC—the absorbance at 700 nm, the Soret peak height relative to the spectrum background, and the Soret peak wavelength. We show that with an increase in the osmolarity, the absorbance at 700 nm increases and the Soret peak relative height decreases. These changes are related to the changes in the RBC volume and the resulting increase in the hemoglobin intracellular concentration and index of refraction. Confocal microscopy and flow cytometry measurements supported these conclusions. The maximum wavelength of the Soret peak increases with increasing osmolarity due to changes in the oxygenation state of hemoglobin. Using these spectrum parameters, the process of osmosis in RBCs can be followed in real time, but it can also be applied to various processes, leading to changes in the volume and shape of RBCs. Therefore, we conclude that UV–Vis absorption spectrophotometry offers a convenient, easily accessible, and cost-effective method to monitor changes in RBC, which can find applications in the field of drug discovery and diagnostics of RBC and hemoglobin disorders.

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Insights into diosgenin against inflammatory bowel disease as functional food based on network pharmacology and molecular docking

Cai,

Mao,

Gao

et al. 2024

Heliyon

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Dioscin: Therapeutic potential for diabetes and complications

Cited by 8 publications

References 126 publications

Optimizing Blood Glucose Regulation in Type 1 Diabetes Patients via Genetic Algorithm-Based Fuzzy Logic Controller Considering Substantial Meal Protocol

Optimizing Blood Glucose Regulation in Type 1 Diabetes Patients via Genetic Algorithm-Based Fuzzy Logic Controller Considering Substantial Meal Protocol

Change in Osmotic Pressure Influences the Absorption Spectrum of Hemoglobin inside Red Blood Cells

Insights into diosgenin against inflammatory bowel disease as functional food based on network pharmacology and molecular docking

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