Diosgenin prevents bone loss on retinoic acid-induced osteoporosis in rats

Zhao, Shouwei; Niu, Fang; Xu, Cailian; Liu, Y.; Ye, L.; Bi, Gel'tser; Chen, L.; Tian, Guangzhao; Nie, Tao

doi:10.1007/s11845-015-1309-2

Cited by 49 publications

(29 citation statements)

References 36 publications

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“…Diosgenin is used for the treatment of osteoporosis in adult rats (64). Malini indicated that seed extract of fennel has estrogenic activity in male and female reproductive organelles and increases the weight of the genital system (65). Oral injection of fennel in rats for 10 days increased the weight of their mammary glands, oviducts, endometria, myometrial, cervixes, and vaginas.…”

Section: Discussionmentioning

confidence: 99%

A review on Electromagnetic fields (EMFs) and the reproductive system

2016

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Environmental factors, such as electromagnetic waves, induce biological and genetic effects. One of the most important physiological systems involved with electromagnetic fields (EMFs) is the genital system. This paper reviews the effects of EMFs on human reproductive organs, female animals, fetus development and the importance of two types of natural antioxidants, i.e., vitamin E and fennel. The studies presented in this review referred to the effects of different exposures to EMFs on the reproductive system, and we tried to show the role of natural antioxidants in reducing the effects of the exposures. Many studies have been done on the effects of ionizing and non-ionizing electromagnetic waves on the cell line of spermatogenesis, sexual hormones, and the structure of the testes. Also, about the hormonal cycle, folliculogenesis and female infertility related to EMF have been given more consideration. In particular, attention is directed to pregnant women due to the importance of their fetuses. However, in addition to the studies conducted on animals, further epidemiological research should be conducted.

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Section: Discussionmentioning

confidence: 99%

A review on Electromagnetic fields (EMFs) and the reproductive system

2016

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“…Recent studies indicated that diosgenin may protect against bone loss, namely, in experimental models of senescence, menopause, and retinoic acid-induced osteoporosis [79–81]. However the mechanism of action is still not clear but can be associated with a modulation on the receptor activator of NF-kB ligand/osteoprotegerin ratio [80].…”

Section: Pharmacology: Recent Datamentioning

confidence: 99%

Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology

Jesus

Martins

Gallardo

et al. 2016

Journal of Analytical Methods in Chemistry

209

125

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Diosgenin, a steroidal sapogenin, occurs abundantly in plants such as Dioscorea alata, Smilax China, and Trigonella foenum graecum. This bioactive phytochemical not only is used as an important starting material for the preparation of several steroidal drugs in the pharmaceutical industry, but has revealed also high potential and interest in the treatment of various types of disorders such as cancer, hypercholesterolemia, inflammation, and several types of infections. Due to its pharmacological and industrial importance, several extraction and analytical procedures have been developed and applied over the years to isolate, detect, and quantify diosgenin, not only in its natural sources and pharmaceutical compositions, but also in animal matrices for pharmacodynamic, pharmacokinetic, and toxicological studies. Within these, HPLC technique coupled to different detectors is the most commonly analytical procedure described for this compound. However, other alternative methods were also published. Thus, the present review aims to provide collective information on the most recent pharmacological data on diosgenin and on the most relevant analytical techniques used to isolate, detect, and quantify this compound as well.

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“…Very recently, a report on favorable effects of high-dose diosgenin in ovariectomized rats has been published (Zhang et al, 2014a). Moreover, diosgenin has been observed to counteract the development of some changes in rats with retinoic acid-induced osteoporosis (Zhao et al, 2015) and in OXYS rats with accelerated senescence (Tikhonova et al, 2015). Also, favorable effects of diosgenin-containing plant organs, their extracts or isolated saponins on the skeletal system have been demonstrated in experimental conditions (Yin et al, 2004;Yin et al, 2010;Chiang et al, 2011;Folwarczna et al, 2014a;Qu et al, 2014;Zhang et al, 2014b).…”

Section: Introductionmentioning

confidence: 99%

Effect of diosgenin, a steroidal sapogenin, on the rat skeletal system.

et al. 2016

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Diosgenin is a steroidal sapogenin present in fenugreek and Dioscorea spp. as glycosides (saponins). Diosgenin has already been reported to inhibit osteoclastogenesis and to stimulate osteogenic activity of osteoblastic cells in vitro, and to exert some antiosteoporotic effects in rats in vivo. The aim of the present study was to investigate the effects of diosgenin administration on the skeletal system of rats with normal estrogen level and with estrogen deficiency induced by bilateral ovariectomy. The experiments were carried out on 3-month-old non-ovariectomized and ovariectomized Wistar rats, divided into control rats and rats receiving diosgenin (50 mg/kg p.o. daily) for 4 weeks. Serum bone turnover markers, bone mass and mineralization, histomorphometric parameters and mechanical properties were studied. Diosgenin improved some investigated parameters in both non-ovariectomized and ovariectomized rats, in which estrogen deficiency induced osteoporotic changes. Diosgenin increased compact bone formation and probably inhibited cancellous bone resorption, which led to improvement of mechanical properties of compact and cancellous bone. In conclusion, this in vivo study demonstrated that diosgenin may be one of sparse compounds increasing bone formation.

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Diosgenin prevents bone loss on retinoic acid-induced osteoporosis in rats

Abstract: Diosgenin can prevent the loss of bone in experimental rats. The mechanism may be that it improves the level of estrogenic hormone of estradiol and inhibits the high bone turnover.

Cited by 49 publications

References 36 publications

A review on Electromagnetic fields (EMFs) and the reproductive system

A review on Electromagnetic fields (EMFs) and the reproductive system

Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology

Effect of diosgenin, a steroidal sapogenin, on the rat skeletal system.

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