2020
DOI: 10.22541/au.159665024.43068911
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Diosmetin modulates lipogenesis and alleviates inflammatory response in nonalcoholic steatohepatitis through STAT1/CXCL10-dependent pathway

Abstract: Background and Purpose: Diosmetin (Dios) exerted a hepatoprotective effect against nonalcoholic steatohepatitis (NASH), but few reports interpreted clearly that the alleviation of Dios against NASH were associated with the inhibition of signal transducers and activators of transcription 1 (STAT1) and macrophage chemotactic ligand 10 (CXCL10). Meanwhile, the mechanism of Dios involved with STAT1/CXCL10 mediated pathway was unknown yet. Experimental Approach: Here, high-fat diet (HFD) and palmitic acid (PA) were… Show more

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