Diospyros , an under-utilized, multi-purpose plant genus: A review

Uddin, Ghias; Patel, Seema; Khan, Ajmal; Halim, Sobia Ahsan; Bawazeer, Saud; Ahmad, Khalid; Muhammad, Naveed; Mubarak, Mohammad S.

doi:10.1016/j.biopha.2017.05.012

Cited by 63 publications

(96 citation statements)

References 77 publications

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“…The major soluble phenols found in Diospyros fruits include phenolic acids, catechins, and hydrolyzed tannins, whereas rutin is an abundant flavonoid . In this respect, 11‐methylgerberinol, a 4‐hydroxycoumarin also present in D. kaki , was found to be a discriminant phenolic metabolite in D. rekoi (Table ) …”

Section: Discussionmentioning

confidence: 82%

“…They can grow in a variety of forest habitats, from lowland dry forests to rain forests. Their fruits are multi‐loculate indehiscent globose berries . Diospyros fruits are produced commercially from a handful of species and are highly appreciated worldwide .…”

Section: Introductionmentioning

confidence: 99%

“…Their fruits are multi‐loculate indehiscent globose berries . Diospyros fruits are produced commercially from a handful of species and are highly appreciated worldwide . Diospyros kaki , Diospyros digyna , Diospyros virginiana , Diospyros lotus , and Diospyros rhombifolia represent the main Diospyros edible fruit‐producing species.…”

Section: Introductionmentioning

confidence: 99%

“…In addition to their leaves, bark, hard wood, and roots, Diospyros fruits are known to have several nutraceutical and pharmacological properties . The bioactive Diospyros secondary metabolites recognized to have sensory and/or therapeutic value are naphthaquinones, anthraquinones, terpenoids, lignans, steroids, flavonoids, naphthalene, phenolic acids, amyrin, and 7‐methyljuglone, among others . Fruit chemical composition has been predominantly determined in D. kaki .…”

Section: Introductionmentioning

confidence: 99%

“…The fruits D. digyna and D. rekoi , locally known as ‘zapote negro’ and ‘zapotillo negro’ respectively, are highly appreciated by the local population, although a fluctuating international demand for the exotic ‘zapote negro’ is common. Contrary to fruits of D. kaki and of other well‐studied species, information of Mesoamerican species such as D. digyna and D. rekoi is scarce to non‐existent . Whereas semi‐domesticated D. digyna fruits have been reported to have high vitamin E content, in addition to relatively abundant levels of carotenoids and phenolic compounds, the latter of which were associated with a strong antioxidant activity, practically no information is available regarding the physicochemical characteristics of wild D. rekoi fruits.…”

Section: Introductionmentioning

confidence: 99%

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Fruits of wild and semi‐domesticated Diospyros tree species have contrasting phenological, metabolic, and antioxidant activity profiles

et al. 2019

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BACKGROUND In contrast to commercial Diospyros species, Mesoamerican fruit‐producing species are scarcely known, particularly wild species that might harbor desirable traits suitable for breeding. Thus, metabolomic, chemical, and antioxidant profiles of fruits harvested from cultivated Diospyros digyna and wild Diospyros rekoi trees during consecutive winter seasons were obtained. Fruits were harvested in habitats having marked differences in soil quality, climate, and luminosity. RESULTS D. digyna fruits were larger and less acid than D. rekoi fruits, whereas antioxidant activity tended to be higher in D. rekoi fruits. Phenolic, flavonoid, and sugar contents also varied significantly between species. Metabolomic analysis allowed the pre‐identification of 519 and 1665 metabolites in negative and positive electrospray ionization (ESI) modes, respectively. Principal component analysis of the positive ESI data explained 51.8% of the variance and indicated clear metabolomic differences between D. rekoi and D. digyna fruits that were confirmed by direct‐injection ESI mass spectrometry profiles. Twenty‐one discriminating metabolites were detected in fruits of both species; D. digyna fruits differentially accumulated lysophospholipids, whereas discriminating metabolites in D. rekoi fruits were chemically more diverse than those in D. digyna fruits. CONCLUSION Domesticated D. digyna fruits have improved physicochemical fruit traits compared with wild D. rekoi fruits, including larger size and lower acidity. The metabolomic and chemical composition of their respective fruits were also significantly different, which in D. rekoi was manifested as a notable season‐dependent increase in antioxidant capacity. Therefore, wild D. rekoi can be considered as an important genetic resource for the improvement of commercial Diospyros fruit quality. © 2019 Society of Chemical Industry

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Section: Discussionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fruits of wild and semi‐domesticated Diospyros tree species have contrasting phenological, metabolic, and antioxidant activity profiles

et al. 2019

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Larvicidal Activity against Spodoptera frugiperda of some Constituents from two Diospyros Species. In silico Pesticide‐likeness Properties, Acetylcholinesterase Activity and Molecular Docking

Pérez‐Valera,

Torres‐Martínez,

Nieto‐Camacho

et al. 2024

Chemistry & Biodiversity

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This report informs for the first time the chemical constituents of Diospyros xolocotzii and Diospyros digyna, the pesticidal and the acetylcholinesterase (AChE) inhibition potential of some compounds calculated by in silico approaches, the larvicidal activity against Spodoptera frugiperda of available compounds, the AChE inhibition of selected compounds, and the results of the molecular docking of the most active ones with this receptor. From the aerial parts of D.xolocotzii were isolated pentacyclic triterpenes (1‐4, 6, 10, 11‐13), phytosterols (15‐17), and isodiospyrin (18), whereas the analysis of aerial parts of D. digyna conducted to the isolation of pentacyclic triterpenes (4, 5, 7‐9, 11‐14), (4S)‐shinanolone (19), and scopoletin (20). For comparison purposes, origanal (21) was chemically prepared from 11. The in silico analysis showed that the tested compounds have pesticide potential. The larvicidal activities of 11 > 13 > 12 indicated that the increase of the oxidation degree at C‐28 increases their bioactivity. Compounds 11 and 21 presented the higher inhibition in the acetylcholinesterase assay, and the higher binding energies, and interactions with AChE by molecular docking. Both Diospyros species are sources of triterpenes with pesticidal potential and the molecular changes in lupane triterpenes correlate with the observed bioactivity and molecular docking.

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Anticancer therapeutic potential of genus Diospyros: From phytochemistry to clinical applications—A review

Rauf,

Akram,

Hafeez

et al. 2024

Food Science & Nutrition

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The genus Diospyros has gained significant attention in the scientific community owing to its diverse bioactivities ascribed to specific bioactive constituents present in different species of this plant. Phytochemicals like flavonoids, terpenoids, and xanthones have been reported to be present in other Diospyros species responsible for their pharmacological properties. These compounds are well known for their diverse potent therapeutic potentials, such as antimicrobial, antioxidant, anti‐inflammatory, and anticancer properties. This review enlightens the details of the Genus Diospyros, ranging from an overview of its species to an in‐depth analysis of phytochemistry, ethnopharmacology, and their potential as anticancer agents. Different species, including Diospyros lotus, Diospyros kaki, Diospyros maritima, Diospyros mespiliformis, and Diospyros tricolor, presented with an enormous range of anticancer activities against human cancer cell cultures. Moreover, this review highlights the results of various in vitro (antiproliferative, cytotoxic effects against), in vivo (inhibition of tumor, apoptosis), and in silico (GLU234, GLU278, and LYS158 protein residues) studies, elucidating its preclinical anticancer potential. The anticancer potential displays inhibition of cellular proliferation, induction of apoptosis, and mitigation of angiogenesis. Furthermore, this review may elaborate the use of traditional knowledge, modern research, and potential therapeutic applications in the field of anticancer ethnopharmacology. As the modern‐day research approaches novel alternatives to combat diseases like cancer, the Genus Diospyros may emerge as a promising avenue with the potential to yield innovative and effective therapeutic agents.

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Diospyros , an under-utilized, multi-purpose plant genus: A review

Cited by 63 publications

References 77 publications

Fruits of wild and semi‐domesticated Diospyros tree species have contrasting phenological, metabolic, and antioxidant activity profiles

Fruits of wild and semi‐domesticated Diospyros tree species have contrasting phenological, metabolic, and antioxidant activity profiles

Larvicidal Activity against Spodoptera frugiperda of some Constituents from two Diospyros Species. In silico Pesticide‐likeness Properties, Acetylcholinesterase Activity and Molecular Docking

Anticancer therapeutic potential of genus Diospyros: From phytochemistry to clinical applications—A review

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