Diphenylhydantoin Sensitivity

Immunological Abnormalities and Hydantoins

“…In the course of the long history of their therapeutic use a broad spectrum of side effects has been attributed to these drugs (Sparberg, 1963), most frequently consisting of visual disturbances, gingival hyperplasia (King, 1952;Sparberg, 1963;Goodman and Gilman, 1970), and various exanthemas (Mandelbaum and Kane, 1941;Loscalzo, 1948;Martin et al, 1954;Watts, 1962). Other side effects described have been haematological abnormalities (Benhamon and Albon, 1953;Best and Paul, 1950;Sparberg, 1963), benign (Siegal and Berkovitz, 1961;Harrington et al, 1962;Holland and Mauer, 1965;Goodman and Gilman, 1970) and, rarely, malignant lymphadenopathies (Hyman and Sommers, 1966), hepatitis (Chaiken et al, 1950;Gropper, 1956;Bajoghli, 1961;Pezzimenti and Andrew, 1970), disease states resembling serum sickness (Bravermann and Levin, 1963), lupus erythematosus (Miescher and Delacretaz, 1953;Lindquist, 1957;Rallison et al, 1961) and periarteritis nodosa (Van Wyk and Hoffman, 1948), and endocrine disorders such as hirsutism (Sparberg, 1963;Kniper, 1969).…”