Diphlorethohydroxycarmalol isolated from Ishige okamurae, a brown algae, a potent α-glucosidase and α-amylase inhibitor, alleviates postprandial hyperglycemia in diabetic mice

Heo, Soo‐Jin; Hwang, Ji-Young; Choi, Jung-In; Han, Ji-Sook; Kim, Hak-Ju; Jeon, You‐Jin

doi:10.1016/j.ejphar.2009.05.017

Cited by 231 publications

(142 citation statements)

References 32 publications

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“…In particular, 4-6 exhibited the most potent -glucosidase inhibition, this corresponding to previous work indicating phlorotannins to be potent -glucosidase inhibitors. [37][38][39]57) These results strongly suggest that the molecular size of the phlorotannins and number of hydroxyl groups present in the molecules are important for strong interaction with enzyme molecules with consequent inhibition of the enzyme. Our results are also consistent with those of a previous study.…”

Section: Discussionmentioning

confidence: 79%

Protein Tyrosine Phosphatase 1B and α-Glucosidase Inhibitory Phlorotannins from Edible Brown Algae,Ecklonia stoloniferaandEisenia bicyclis

Moon

Islam

Ahn

et al. 2011

Bioscience, Biotechnology, and Biochemistry

137

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Section: Discussionmentioning

confidence: 79%

Protein Tyrosine Phosphatase 1B and α-Glucosidase Inhibitory Phlorotannins from Edible Brown Algae,Ecklonia stoloniferaandEisenia bicyclis

Moon

Islam

Ahn

et al. 2011

Bioscience, Biotechnology, and Biochemistry

137

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“…Over the past several decades seaweeds have generated an enormous amount of interest in the pharmacological industry with enormous medicinal properties. They are rich in antioxidants such as alkaloids, flavonoids, pigments, carotenoids, enzymes and polysaccharides (Heo et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Potential antibacterial activity of crude extracts and silver nanoparticles synthesized from Sargassum wightii

Thirumalairaj¹,

Vijayan²,

Durairaj³

et al. 2014

Int Curr Pharm J

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The present work investigates the antibacterial activity of silver nanoparticles (Ag-NPs) synthesized by biological method using Sargassum wightii. The fresh live seaweed was collected from the Mandapam coast of Tamilnadu, India. Solvent extract was prepared using acetone, petroleum ether and methanol. Aqueous extract of the seaweed was also used for the synthesis of silver Ag-NPs. Seaweed extract is used as a reducing agent of 2mM silver nitrate solution for the synthesis of Ag-NPs. Periodical monitoring of reaction mixture was done using UV-vis spectroscopy at 300-750 nm. The scanning electron microscopy (SEM) of the sample confirms the presence of Ag-NPs. The antibacterial activity of solvent extract was done by Minimal inhibitory concentration (MIC) assay. The methanol extract of the seaweed at a concentration of 250µg/ml exhibited potent antimicrobial activity against the test microorganism. The zone of inhibition ranging from 8-14 mm was observed with different extracts. The antibacterial activity of the synthesized Ag-NPs against the organism was also done by MIC test. The MIC of Ag-NPs was found to be 130µg/ml for all pathogenic microorganisms selected for the study. The zone of inhibition against Bacillus cereus, Bacillus anhtracis, Staphylococcus aureus and Vibrio alginoyticus were found to be 10, 8, 10 and 9 mm, respectively. The synthesized Ag-NPs exhibited significant antimicrobial activity against the selected microorganisms than the solvent extract of seaweed.DOI: http://dx.doi.org/10.3329/icpj.v3i10.20337 International Current Pharmaceutical Journal, September 2014, 3(10): 322-325

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“…It was reported that many synthetic saccharides may reduce plasma glucose via retarding the liberation of glucose from dietary complex carbohydrates in the small intestine. However, the application of these inhibitors has often been reported to induce disturbances in the gastrointestinal tract, including flatulence, diarrhea and abdominal pain (Heo et al 2009). …”

Section: Introductionmentioning

confidence: 99%

“…One of the therapeutic approaches for decreasing postprandial hyperglycemia is to retard absorption of glucose by inhibiting carbohydrate hydrolyzing enzymes such as aamylase in the digestive organs (Heo et al 2009). It was reported that many synthetic saccharides may reduce plasma glucose via retarding the liberation of glucose from dietary complex carbohydrates in the small intestine.…”

Section: Introductionmentioning

confidence: 99%

Beneficial effects of fermented sardinelle protein hydrolysates on hypercaloric diet induced hyperglycemia, oxidative stress and deterioration of kidney function in wistar rats

et al. 2017

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This study investigated the potential effects of fermented sardinelle protein hydrolysates (FSPHs) obtained by two proteolytic bacteria, Bacillus subtilis A26 (FSPH-A26) and Bacillus amyloliquefaciens An6 (FSPHAn6), on hypercaloric diet (HCD) induced hyperglycemia and oxidative stress in rats. Effects of FSPHs on blood glucose level, glucose tolerance, a-amylase activity and hepatic glycogen content were investigated, as well as their effect on the oxidative stress state. Biochemical findings revealed that, while undigested sardinelle proteins did not exhibit hypoglycemic activity, oral administration of FSPHs to HCD-fed rats reduced significantly a-amylase activity as well as glycemia and hepatic glycogen levels. Further, the treatment with FSPHs improved the redox status by decreasing the levels of lipid peroxidation products and increasing the activities of the antioxidant enzymes (superoxide dismutase, glutathione peroxidase and catalase) and the level of glutathione in the liver and kidneys, as compared to those of HCD-fed rats. FSPHs were also found to exert significant protective effects on liver and kidney functions, evidenced by a marked decrease in alkaline phosphatase activity and a modulation of creatinine and uric acid contents. These results indicated the beneficial effect of FSPHs on the prevention from hyperglycemia and oxidative stress.

show abstract

Diphlorethohydroxycarmalol isolated from Ishige okamurae, a brown algae, a potent α-glucosidase and α-amylase inhibitor, alleviates postprandial hyperglycemia in diabetic mice

Cited by 231 publications

References 32 publications

Protein Tyrosine Phosphatase 1B and α-Glucosidase Inhibitory Phlorotannins from Edible Brown Algae,Ecklonia stoloniferaandEisenia bicyclis

Protein Tyrosine Phosphatase 1B and α-Glucosidase Inhibitory Phlorotannins from Edible Brown Algae,Ecklonia stoloniferaandEisenia bicyclis

Potential antibacterial activity of crude extracts and silver nanoparticles synthesized from Sargassum wightii

Beneficial effects of fermented sardinelle protein hydrolysates on hypercaloric diet induced hyperglycemia, oxidative stress and deterioration of kidney function in wistar rats

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