Direct analysis in real time mass spectrometry with collision‐induced dissociation for structural analysis of synthetic cannabinoids

Musah, Rabi A.; Domin, Marek; Cody, Robert B.; Lesiak, Ashton D.; Dane, A. John; Shepard, Jason R. E.

doi:10.1002/rcm.6354

Cited by 64 publications

(63 citation statements)

References 25 publications

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“…9) We have used accurate mass, isotopic measurements and fragment ions to detect the presence of drugs of abuse including new designer drugs that are becoming a growing threat. 10,11) Targeted methods are not applicable to the detection of new and unexpected drugs that are appearing "on the street" every day.…”

Section: Resultsmentioning

confidence: 99%

What Is the Opposite of Pandora’s Box? Direct Analysis, Ambient Ionization, and a New Generation of Atmospheric Pressure Ion Sources

Cody

2013

Mass Spectrometry

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The introduction of DART and DESI sources approximately seven years ago led to the development of a new series of atmospheric pressure ion sources referred to as "ambient ionization" sources. These fall into two major categories: spray techniques like DESI or plasma techniques like DART. The selectivity of "direct ionization," meaning analysis without chromatography and with little or no sample preparation, depends on the mass spectrometer selectivity. Although high resolution and tandem mass spectrometry are valuable tools, rapid and simple sample preparation methods can improve the utility of ambient ionization methods. The concept of ambient ionization has led to the realization that there are many more ways to form ions than might be expected. An interesting example is the use of a flint-and-steel spark source to generate ions from compounds such as phenolphthalein and Gramicidin S.

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Section: Resultsmentioning

confidence: 99%

What Is the Opposite of Pandora’s Box? Direct Analysis, Ambient Ionization, and a New Generation of Atmospheric Pressure Ion Sources

Cody

2013

Mass Spectrometry

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“…[89][90][91] Techniques like NMR and GC-MS are in most cases needed, preferably in combination, to enable a proper identification of structural elements and determination of the chemical structure. 92 Other complementary techniques like QTOF-HRMS 10, 93 and GC-FTIR 91,94 are useful alternatives that facilitate the identification.…”

Section: Structural Elucidation Of Unknownsmentioning

confidence: 99%

Synthesis and spectroscopic characterization of emerging synthetic cannabinoids and cathinones

Carlsson¹

2016

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The application of different analytical techniques is fundamental in forensic drug analysis. In the wake of the occurrence of large numbers of new psychoactive substances possessing similar chemical structures as already known ones, focus has been placed on applied criteria for their univocal identification. These criteria vary, obviously, depending on the applied technique and analytical approach. However, when two or more substances are proven to have similar analytical properties, these criteria no longer apply, which imply that complementary techniques have to be used in their differentiation.This work describes the synthesis of some structural analogues to synthetic cannabinoids and cathinones based on the evolving patterns in the illicit drug market. Six synthetic cannabinoids and six synthetic cathinones were synthesized, that, at the time for this study, were not as yet found in drug seizures. Further, a selection of their spectroscopic data is compared to those of already existing analogues; mainly isomers and homologues. The applied techniques were mass spectrometry (MS), Fourier transformed infrared (FTIR, gas phase) spectroscopy and nuclear magnetic resonance (NMR) spectroscopy. In total, 59 different compounds were analyzed with the selected techniques.

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“…DART-MS has shown success in forensic analyses of pharmaceuticals [13][14][15], biological samples [16,17], illicit drugs [18][19][20][21][22][23][24][25], chemical warfare agents [26], inks [27], and explosives [2][3][4][5]. Analyses of organic explosives directly from many surfaces including glass, asphalt shingle, polyurethane foam, wood and metal have typically yielded clean spectra [3].…”

Section: Introductionmentioning

confidence: 99%

Trace analysis of energetic materials via direct analyte-probed nanoextraction coupled to direct analysis in real time mass spectrometry

Clemons

Dake

Sisco

et al. 2013

Forensic Science International

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Direct analysis in real time mass spectrometry with collision‐induced dissociation for structural analysis of synthetic cannabinoids

Cited by 64 publications

References 25 publications

What Is the Opposite of Pandora’s Box? Direct Analysis, Ambient Ionization, and a New Generation of Atmospheric Pressure Ion Sources

What Is the Opposite of Pandora’s Box? Direct Analysis, Ambient Ionization, and a New Generation of Atmospheric Pressure Ion Sources

Synthesis and spectroscopic characterization of emerging synthetic cannabinoids and cathinones

Trace analysis of energetic materials via direct analyte-probed nanoextraction coupled to direct analysis in real time mass spectrometry

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