2024
DOI: 10.1101/2024.04.15.589515
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Direct and indirect striatal projecting neurons exert strategy-dependent effects on decision-making

Elena Chaves Rodriguez,
Jérémie Naudé,
Daniel Rial
et al.

Abstract: Striatum constitutes one of the key nodes of the decision-making circuit, with differing roles depending on the striatal localization and both direct and indirect pathway Striatal Projecting Neurons (d- and i-SPNs) populations. In a gambling task adapted to mice, we leveraged a computational characterization of the diversity in cognitive profiles to delve further into the striatal roles in decision-making. Individual decision-making profiles could be described as a combination between archetypal strategies (Op… Show more

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