Direct bilirubin levels are prognostic in non-small cell lung cancer

Song, Yawei; Xin-huai, Gao; Hong, Yongqing; Wang, Lixin

doi:10.18632/oncotarget.23184

Cited by 12 publications

(10 citation statements)

References 17 publications

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“… 34 Those with elevated bilirubin had a longer overall survival than those with normal bilirubin. Some studies have shown that serum bilirubin is a positive prognostic factor in lung cancer with strong antioxidant and antitumour effects 26 , 35 which is consistent with ours. However, the relationship between bilirubin and lung cancer survival remains controversial.…”

Section: Discussionsupporting

confidence: 92%

<p>Bilirubin Can Be Used as a Prognostic Factor for Lung Adenocarcinoma Patients with EGFR Mutations</p>

Geng

Mei

et al. 2020

OTT

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Background and Objectives Non-small cell lung cancer (NSCLC) patients with an epidermal growth factor receptor ( EGFR ) mutation demonstrate only a median progression-free survival (PFS) of 8 to 10 months and undergo EGFR tyrosine kinase inhibitors (EGFR-TKIs) therapy. For decades, bilirubin has been reported to be associated with the onset and prognosis of lung cancer as a prooxidant. This study aimed to investigate the prediction of pretreatment circulating bilirubin for PFS in lung adenocarcinoma (LAC) patients who underwent EGFR-TKIs targeted therapy. Patients and Methods LAC cases diagnosed and undergone EGFR-TKIs targeted therapy at The First Affiliated Hospital of Zhengzhou University between 2013 and 2015 were retrospectively reviewed. A total of 180 patients were studied according to inclusion and exclusion criteria. Follow-up data were collected for all patients until the disease progressed. Results Univariate analysis showed that the levels of pretreatment total bilirubin (TBIL), indirect bilirubin (IBIL) and direct bilirubin (DBIL) were related to PFS (all p <0.05). Considering the close relationship among the three factors, we combined TBIL, IBIL and DBIL into one total factor, which is called bilirubin. Kaplan–Meier survival curves and Log rank tests indicated that patients with lower bilirubin levels had a shorter median PFS than those with higher bilirubin levels (8 vs. 15 months; p= 0.002). Multivariate analysis demonstrated that pretreatment bilirubin is an independent prognostic factor (HR=0.454, CI: 0.267–0.773, p= 0.004). Conclusion This study confirms that bilirubin can predict the prognosis of LAC patients who had undergone EGFR-TKIs targeted therapy.

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Section: Discussionsupporting

confidence: 92%

<p>Bilirubin Can Be Used as a Prognostic Factor for Lung Adenocarcinoma Patients with EGFR Mutations</p>

Geng

Mei

et al. 2020

OTT

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“…Also, elevated IgE levels can be found in COPD patients [29]. In addition, TNF-α, IL-6, IL-8, NLR, PLR, IgE have been associated with LC risk in healthy subjects, being IL-6, lymphocytes, neutrophils, NLR, platelets, PLR, fibrinogen, A1AT, CRP and bilirubin poor prognostic factors in LC patients [11, 14, 30–32]. According to our results (Fig.…”

Section: Discussionsupporting

confidence: 57%

“…In fact, various blood markers of inflammation have been evaluated separately in patients either with COPD or with LC and other malignant tumors (Additional file 1: Table S1). These markers include C-reactive protein (CRP), platelet, neutrophil, and lymphocyte numbers but especially include neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), mean platelet volume (MPV), alpha-1-antitripsin (A1AT), fibrinogen, cholesterol or bilirubin [10–14]. Therefore, the increased risk of developing LC in patients with COPD could be related to the existence of a previous inflammation, making them more susceptible to the carcinogenic components of tobacco.…”

Section: Introductionmentioning

confidence: 99%

Predictive value of a series of inflammatory markers in COPD for lung cancer diagnosis: a case-control study

et al. 2019

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Background There is a relationship between Chronic Obstructive Pulmonary Disease (COPD) and the development of lung cancer (LC). The aim of this study is to analyse several blood markers and compare their concentrations in patients with only COPD and LC + COPD. Methods Case-control study with cases presenting combined LC and COPD and two control groups (patients presenting only COPD and patients presenting only LC). We also included LC patients with descriptive purposes. In both groups, peripheral blood analyses of TNF-α, IL-6, IL-8, total leukocyte, lymphocyte and neutrophil counts, neutrophil-to-lymphocyte ratio, total platelet count, mean platelet volume, platelet-to-lymphocyte ratio, alpha 1-antitripsin (A1AT), IgE, C-reactive protein, fibrinogen, cholesterol and bilirubin were performed. We developed univariate and multivariate analyses of these markers, as well as a risk score variable, and we evaluated its performance through ROC curves. Results We included 280 patients, 109 cases (LC + COPD), 83 controls (COPD) and 88 LC without COPD. No differences were observed in the distribution by sex, age, BMI, smoking, occupational exposure, lung function, GOLD stage or comorbidity. Patients with LC + COPD had significantly higher levels of neutrophils [OR 1.00 (95%CI 1.00–1.00), p = 0.03] and A1AT [OR 1.02 (95%CI 1.01–1.03), p = 0.003] and lower cholesterol levels [OR 0.98 (95%CI 0.97–0.99), p = 0.009] than COPD controls. We developed a risk score variable combining neutrophils, A1AT and cholesterol, achieving a sensitivity of 80%, a negative predictive value of 90.7% and an area under the curve of 0.78 (95%CI 0.71–0.86). Conclusions COPD patients who also have LC have higher levels of neutrophils and A1AT and lower of cholesterol. These parameters could be potentially predicting biomarkers of LC in COPD patients. Electronic supplementary material The online version of this article (10.1186/s12931-019-1155-2) contains supplementary material, which is available to authorized users.

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“…However, the absolute direct bilirubin is more clinically useful than the direct-total bilirubin ratio. Song et al [56] showed DBIL levels are not only associated with tumor progression and first-line platinum chemotherapy reactions, but also are correlated with total survival after lymph node metastasis.…”

Section: Discussion and Future Workmentioning

confidence: 99%

A New Evolutionary Machine Learning Approach for Identifying Pyrene Induced Hepatotoxicity and Renal Dysfunction in Rats

Zhu

Huang

et al. 2019

IEEE Access

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Pyrene, composed of four fused benzene rings, is a polycyclic aromatic hydrocarbon (PAH) that has served as a model compound for evaluating the toxic effects of PAHs. In this paper, 114 male rats were dosed daily by oral gavage with either vehicle (corn oil) or pyrene (1500 mg/kg/day) for four days. A method based on the gray wolf optimization-enhanced machine learning approach was then developed to identify pyrene poisoning in rats using the indices from blood analysis. The results showed that there were significant differences in blood analysis indices between the control and the pyrene groups (p < 0.05). In terms of feature selection, the most important correlated indices were liver to body weight ratio, the absolute value of leukomonocyte, the percentage of monocyte, serum albumin, direct bilirubin, urea nitrogen, and uric acid. This method was shown to have an accuracy rate of 94.62% (ACC), 0.8988 Matthews correlation coefficients (MCCs), 91.71% sensitivity, and 98.33% specificity. Empirical analysis indicates that this method represents a new and accurate approach for detecting pyrene poisoning.

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Direct bilirubin levels are prognostic in non-small cell lung cancer

Cited by 12 publications

References 17 publications

<p>Bilirubin Can Be Used as a Prognostic Factor for Lung Adenocarcinoma Patients with EGFR Mutations</p>

<p>Bilirubin Can Be Used as a Prognostic Factor for Lung Adenocarcinoma Patients with EGFR Mutations</p>

Predictive value of a series of inflammatory markers in COPD for lung cancer diagnosis: a case-control study

A New Evolutionary Machine Learning Approach for Identifying Pyrene Induced Hepatotoxicity and Renal Dysfunction in Rats

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