Direct C(sp<sup>3</sup>)–H functionalization with aryl and alkyl radicals as intermolecular hydrogen atom transfer (HAT) agents

Tu, Jia-Lin; Huang, Binbin

doi:10.1039/d4cc03383c

Chem. Commun.

2024

DOI: 10.1039/d4cc03383c

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Direct C(sp³)–H functionalization with aryl and alkyl radicals as intermolecular hydrogen atom transfer (HAT) agents

Jia-Lin Tu,

Binbin Huang

Abstract: Recent years have witnessed the emergence of direct intermolecular C(sp3)–H bond functionalization using in situ generated aryl/alkyl radicals as a unique class of hydrogen atom transfer (HAT) agents.

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Cited by 6 publications

References 213 publications

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Catalytic Construction of C(sp³)−Ge Bonds: Recent Advances and Future Perspectives

Tu,

Huang

2024

Adv Synth Catal

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Germanium (Ge), a congener of carbon, possesses unique properties that hold extensive potential for applications across multiple domains. Recent years have seen significant progress in the development of carbon‐germanium bond formation strategies, particularly those for more challenging C(sp3)‐Ge bonds. This review systematically summarizes the recent advances in C(sp3)‐Ge bond forming methodologies, with particular emphasis on (1) the versatility of transition‐metals, including iron, nickel, copper, rhodium and palladium, as catalysts in broadening reaction scope and controlling selectivity; (2) the powerfulness of organic photocatalysis in achieving mild and selective bond formation, and (3) the sustainability of catalytic electrosynthesis in facilitating chemical oxidant‐/reductant‐free conversions. Additionally, examples of (4) non‐catalytic strategies are also discussed. The representative scopes, as well as mechanistic proposals, of these protocols are highlighted. Through an overview on the current state of research, this review aims to offer insights into the catalytic construction of C(sp3)‐Ge bonds, and provide perspectives on future research directions to address the current challenges.

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Catalytic Construction of C(sp³)−Ge Bonds: Recent Advances and Future Perspectives

Tu,

Huang

2024

Adv Synth Catal

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Photo- and electro-chemical strategies for indazole synthesis

Huang

2024

Tetrahedron Chem

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Recent progress in metal-catalyzed C(sp³)-P bond formation

Tu,

Shen,

Huang

2024

Tetrahedron

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Direct C(sp³)–H functionalization with aryl and alkyl radicals as intermolecular hydrogen atom transfer (HAT) agents

Abstract: Recent years have witnessed the emergence of direct intermolecular C(sp3)–H bond functionalization using in situ generated aryl/alkyl radicals as a unique class of hydrogen atom transfer (HAT) agents.

Cited by 6 publications

References 213 publications

Catalytic Construction of C(sp³)−Ge Bonds: Recent Advances and Future Perspectives

Catalytic Construction of C(sp³)−Ge Bonds: Recent Advances and Future Perspectives

Photo- and electro-chemical strategies for indazole synthesis

Recent progress in metal-catalyzed C(sp³)-P bond formation

Contact Info

Product

Resources

About

Direct C(sp3)–H functionalization with aryl and alkyl radicals as intermolecular hydrogen atom transfer (HAT) agents

Abstract: Recent years have witnessed the emergence of direct intermolecular C(sp3)–H bond functionalization using in situ generated aryl/alkyl radicals as a unique class of hydrogen atom transfer (HAT) agents.

Cited by 6 publications

References 213 publications

Catalytic Construction of C(sp3)−Ge Bonds: Recent Advances and Future Perspectives

Catalytic Construction of C(sp3)−Ge Bonds: Recent Advances and Future Perspectives

Photo- and electro-chemical strategies for indazole synthesis

Recent progress in metal-catalyzed C(sp³)-P bond formation

Contact Info

Product

Resources

About

Direct C(sp³)–H functionalization with aryl and alkyl radicals as intermolecular hydrogen atom transfer (HAT) agents

Catalytic Construction of C(sp³)−Ge Bonds: Recent Advances and Future Perspectives

Catalytic Construction of C(sp³)−Ge Bonds: Recent Advances and Future Perspectives