Direct correlation between serum homocysteine level and insulin resistance index in patients with subclinical hypothyroidism: Does subclinical hypothyroidism increase the risk of diabetes and cardio vascular disease together?

Ebrahimpour, Anahita; Vaghari‐Tabari, Mostafa; Qujeq, Durdi; Moein, Soheila; Moazezi, Zoleika

doi:10.1016/j.dsx.2018.05.002

Cited by 27 publications

(25 citation statements)

References 22 publications

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“…Therefore, the thyroid function screening should be also paid attention in MetS subjects. In terms of the physiological function, thyroid hormones have a range of effects on energy homeostasis, lipid and glucose metabolism, and blood pressure, most of which are considered as important components of MetS, so it is reasonable that metabolic alterations could be observed in subjects with SCH [23][24][25] . On the other hand, Chang, C. H. et al also found that Individuals with MetS are at a greater risk for developing SCH, which further verified the association between SCH and MetS, but more exact mechanism needed to be explored 26 .…”

Section: Discussionmentioning

confidence: 99%

Subclinical hypothyroidism and anxiety may contribute to metabolic syndrome in Sichuan of China: a hospital-based population study

Zhang

Luo

et al. 2020

Sci Rep

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the prevalence of Metabolic syndrome (MetS) in Sichuan of china has not yet been estimated. Meanwhile the association among anxiety, subclinical hypothyroidism (SCH) and MetS was less wellstudied. The data was retrieved retrospectively from Health Promotion Center of West China Hospital database between 2014 and 2017. Internal validation by randomizing into training and testing panel by 9:1 and external validation with National Health and Nutrition Examination Survey (NHNES) were conducted. 19006 subjects were included into analysis, and 3530 (18.6%) of them were diagnosed with MetS. In training panel, age, sex (male), SCH (presence), SAS score, alcohol (Sometimes & Usual) and smoking (Active) were identified as independent risk factors for MetS, which was confirmed in testing panel internally. NHNES data validated externally the association between free thyroxine (fT4) and MetS components. The C-indices of predicting MetS nomogram were 0.705 (95% CI: 0.696-0.714) and 0.728 (95% CI: 0.701-0.754) in training and testing panel respectively. In conclusion, MetS prevalence was 18.6% in Sichuan. SCH and anxiety may be associated with MetS independently. A risk scale-based nomogram with accurate and objective prediction ability was provided for check-up practice, but more cohort validation was needed.

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Section: Discussionmentioning

confidence: 99%

Subclinical hypothyroidism and anxiety may contribute to metabolic syndrome in Sichuan of China: a hospital-based population study

Zhang

Luo

et al. 2020

Sci Rep

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“…However, as for SCH, although several studies have shown that SCH was significantly associated with CVD [28,29] or carotid IMT [5], a predictor of cardiovascular events, the risk of CVD may not increase in patients with mild SCH, and subjects > 65 years may not have an increased mortality [30]. Moreover, role of hyperhomocysteinemia in patients with SCH and an increased CVD risk is unclear [12][13][14][15][16][17][18][19]21]. As a result, clinicians are uncertain whether they should start early therapeutic intervention with L-T4.…”

Section: Discussionmentioning

confidence: 99%

“…Of the 36 articles initially selected, 12 studies were finally identified that met the inclusion criteria (▶Fig. 1) [10][11][12][13][14][15][16][17][18][19][20][21]. The characteristics of the subjects in both the SCH and euthyroid groups are summarized with the results in ▶table 1.…”

Section: Study and Patient Characteristicsmentioning

confidence: 99%

“…Hyperhomocysteinemia is proposed as a risk factor for CVD in those with overt hypothyroidism; yet, as SCH and overt hypothyroidism have a similar etiology, the tHcy level may also be valuable in patients with SCH. However, it is controversial whether SCH is associated with hyperhomocysteinemia; a few studies have shown that the tHcy level is elevated in those with SCH [10][11][12][13], while others have conflicting findings [14][15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

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Association Between Plasma Homocysteine Levels and Subclinical Hypothyroidism in Adult Subjects: A Meta-Analysis

Shou-fa

Liu

Zhang³

et al. 2020

Horm Metab Res

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AbstractIncreased plasma homocysteine (Hcy) levels have been widely documented in patients with overt hypothyroidism; however, the significance of Hcy level changes in patients with subclinical hypothyroidism (SCH) remains controversial. The aim of this meta-analysis was to determine the Hcy status in patients with SCH compared with euthyroid subjects. We searched PubMed, Embase, and Cochrane Library databases prior to December 2019 to identify eligible studies and assessed the quality of selected studies using the Newcastle-Ottawa Quality Assessment Scale. Publication bias was evaluated by Begg’s test and Egger’s test. Meta-regression analysis was conducted to investigate the source of heterogeneity. A likely source of heterogeneity was the year of the study. All statistical analyses were performed with RevMan 5.3 and Stata 12.0 software. Our meta-analysis of twelve observational studies with 684 patients showed that those with SCH aged between 18 and 65 years old were associated with a slightly increased plasma Hcy level compared with euthyroid controls. The pooled result of the weighted mean difference (WMD) of increased tHcy levels was 1.16 μmol/l (95% CI: 0.51, 1.82; p=0.0005). The Hcy level in patients with SCH aged between 18 and 65 years old is significantly increased compared to euthyroid controls.

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“…Under normal conditions, Hcy can be catabolized in the body, which maintains a low serum Hcy concentration . However, in daily life, primary and secondary causes may affect the metabolism of serum Hcy, resulting in the accumulation of Hcy in the blood and an increase in the serum Hcy concentration . Clinical and epidemiological data have confirmed that the Hcy level is higher in patients with diabetes compared with healthy individuals and positively correlated with the severity of the disease .…”

Section: Introductionmentioning

confidence: 99%

A compound reflects the level of homocysteine based on Rhodamine B and its ability to respond to homocysteine in the plasma of diabetic patients

Zhao

Cheng

Zhu

2020

Clinical Laboratory Analysis

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Background:The level of homocysteine (Hcy) is significantly elevated in the plasma of patients with diabetes. The increased plasma Hcy level is positively correlated with the severity of the disease and is one of the important causes of diabetic complications. Methods:We designed and synthesized a compound could reflect the level of Hcy based on rhodamine B, and the structure was verified by 1H-NMR and EI-HRMS.Then, the linearity, repeatability, selectivity, and cellar toxicity, the effects of the fluid viscosity and pH of compound on Hcy were measured; meanwhile, the response of Hcy level in the plasma of diabetic patients was detected.Results: This is a novel compound that has never been reported. The compound showed a satisfactory linear range and repeatability at the viscosity and pH of physiological fluid. In addition, the compound was capable of evading the interference from other amino acids and metal ions, and it exhibited high selectivity toward Hcy. Conclusion:The compound showed increased responsiveness to plasma Hcy in patients with diabetes in comparison with healthy individuals and effectively reflected plasma Hcy levels in healthy individuals and diabetic patients. Therefore, the compound is expected to be used in the diagnosis of diabetes mellitus. K E Y W O R D Sdiabetic patients, homocysteine, rhodamine B

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Direct correlation between serum homocysteine level and insulin resistance index in patients with subclinical hypothyroidism: Does subclinical hypothyroidism increase the risk of diabetes and cardio vascular disease together?

Cited by 27 publications

References 22 publications

Subclinical hypothyroidism and anxiety may contribute to metabolic syndrome in Sichuan of China: a hospital-based population study

Subclinical hypothyroidism and anxiety may contribute to metabolic syndrome in Sichuan of China: a hospital-based population study

Association Between Plasma Homocysteine Levels and Subclinical Hypothyroidism in Adult Subjects: A Meta-Analysis

A compound reflects the level of homocysteine based on Rhodamine B and its ability to respond to homocysteine in the plasma of diabetic patients

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