Direct Drug Determination by Selective Sample Enrichment on an Imprinted Polymer

Sellergren, Börje

doi:10.1021/ac00081a036

Cited by 487 publications

(227 citation statements)

References 17 publications

Supporting

Mentioning

220

Contrasting

Unclassified

Order By: Relevance

“…Nowadays, MIPs have been largely applied to the extraction or to clean up of target analytes from various complex matrices such environmental, biological, food and pharmaceuticals [4][5][6]. Concerning the pharmaceutical field, many examples deal with the extraction of a drug by MIP from tablets [7], plasma [8][9][10], serum [11], or from urine [12][13][14][15]. MIPs can be synthesized by three different imprinting approaches: the non covalent, the covalent and the semi-covalent methods.…”

Section: Introductionmentioning

confidence: 99%

A Molecularly Imprinted Polymer for the Selective Solid-Phase Extraction of Ibuprofen from Urine Samples

Lagha¹

2011

TOCBMJ

View full text Add to dashboard Cite

A molecularly imprinted polymer (MIP) was synthesized and evaluated to selectively extract ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), from human urine. The synthesis of the MIP was performed in dimethylformamide with acrylamide as functional monomer, ethylene glycol dimethacrylate as the cross linker and ibuprofen template as the target drug. The performance of the synthesized MIP as solid phase extraction (SPE) packing to recognize and bind ibuprofen was evaluated against other structurally related NSAIDs such as naproxen and ketoprofen. Using a mixture of acetonitrile-water (1/9 v/v) as a solvent for ibuprofen the binding recovery at approximately 90% was obtained for developed MIP in optimized conditions. Batch rebinding capacity of ibuprofen was determined from the derived Freundlich isotherm and was found to be 1.45 mol g -1 . Furthermore, a higher selectivity of developed MIP for ibuprofen over structurally related analogues was observed. The synthesized MIP has enabled the direct percolation of humane urine and the easy elimination of endogenous compounds from it with simple aqueous washing of the MIP-SPE packing. HPLC analysis has confirmed the high extraction recovery (ca. 85 %) of ibuprofen from such urine samples with use of proposed MIP-SPE system.

show abstract

Section: Introductionmentioning

confidence: 99%

A Molecularly Imprinted Polymer for the Selective Solid-Phase Extraction of Ibuprofen from Urine Samples

Lagha¹

2011

TOCBMJ

View full text Add to dashboard Cite

show abstract

“…The molecularly imprinted polymeric materials can recognize target molecules with the shape-complementary cavities, and their applications in the recognition of biological compounds, drugs, and agrochemicals have been studied. [4][5][6][7] The polymers such as polyacrylate, polystyrene, and polysilane include one of the most frequently used recognition matrices. 8 The great potentiality of conducting polymers toward a number of applications, such as batteries, 9 sensors [10][11][12] and ionselective electrodes, 13,14 has attracted much attention.…”

mentioning

confidence: 99%

Highly Selective Molecularly Imprinted Overoxidized Polypyrrole Colloids: One-Step Preparation Technique

et al. 2002

View full text Add to dashboard Cite

“…The first in-line MISPE was described by Sellergren for the determination of pentamidine in urine [107]. And the first evaluation of MIPs as in-line concentrator in CE was reported by Lara et al [108].…”

Section: 113mentioning

confidence: 99%

Recent advances in solid-phase sorbents for sample preparation prior to chromatographic analysis

Wen

Chen

et al. 2014

TrAC Trends in Analytical Chemistry

342

123

View full text Add to dashboard Cite

A B S T R A C TSample preparation is a crucial bottleneck in the whole analytical process. Solid-phase sorbents (SPSs) have aroused increasing interest in research on sample preparation, as they have key roles in obtaining high clean-up and enrichment efficiency in the analysis of trace targets present in complex matrices. The objective of this review is to provide a broad overview of the recent advances and applications of SPSs in sample preparation prior to chromatographic analysis, during the period 2008-13. We include SPSs, such as molecularly-imprinted polymers, carbon nanomaterials, metallic nanoparticles and metal organic frameworks, focusing on solid-phase extraction, solid-phase microextraction, matrix solid-phase dispersion and stir-bar sorptive extraction of typical pollutants in environmental, biological, food and pharmaceutical samples. We propose remaining challenges and future perspectives to improve development of new SPSs and to apply them further.

show abstract

Direct Drug Determination by Selective Sample Enrichment on an Imprinted Polymer

Cited by 487 publications

References 17 publications

A Molecularly Imprinted Polymer for the Selective Solid-Phase Extraction of Ibuprofen from Urine Samples

A Molecularly Imprinted Polymer for the Selective Solid-Phase Extraction of Ibuprofen from Urine Samples

Highly Selective Molecularly Imprinted Overoxidized Polypyrrole Colloids: One-Step Preparation Technique

Recent advances in solid-phase sorbents for sample preparation prior to chromatographic analysis

Contact Info

Product

Resources

About