Direct electrical stimulation of specific human brain structures and bilateral electrodermal activity

Limbic Activation and Psychophysiologic Responses to Aversive Visual Stimuli Interaction with Cognitive Task

“…While we cannot adequately resolve individual thalamic nuclei with this PET methodology, a focus centered over a limbic nucleus reinforces the face validity of the results. Mangina and Beuzeron-Mangina (1996) found that direct stimulation of the human amygdala elicited ipsilateral SCRs, however the difference between direct stimulation and the more "physiologic" method used in our study could account for the differences in laterality. Others reported that amygdaloid lesions abolish conditioning of the SCR by emotional stimuli, while sparing the skin conductance component of the orienting response (Bechara et al 1995).…”

“…We observed activation in both amygdalae, but the task specific interaction and the correlation with the SCR were observed predominantly on the right. Others have noted laterality (Mangina and Beuzeron-Mangina 1996) or differential activation in right vs. left amygdala Morris et al 1998). Whereas it is possible that this merely reflects the low experimental power, it is also possible that activation thresholds or the time course differ for right and left amygdalae, or that they play differential roles in the modulation of emotions.…”

“…Extracellular recording, electrical stimulation and lesion studies implicate the amygdala and related limbic structures in the expression or modulation of emotional responses LeDoux 1986;McGaugh et al 1996). Animal and human studies suggest that these same regions modulate autonomic components of emotional responses (Bechara et al 1995;LaBar et al 1995;Mangina and Beuzeron-Mangina 1996). Recent functional neuroimaging studies have demonstrated that the amygdala and cortico-limbic structures respond to fearful/aversive stimuli (Irwin et al 1996;Reiman et al 1997;Taylor et al 1998;LaBar et al 1998;Morris et al 1999a), perception of facial expressions of fear and disgust (Breiter et al 1996;Phillips et al 1997;Whalen et al 1998), perception of linguistic threat (Isen-berg et al 1999) and of non verbal emotional vocalization (Morris et al 1999b).…”

Dissociation, Epileptiform Discharges and Chaos in the Brain: Toward a Neuroscientific Theory of Dissociation

“…Psychophysiology of bilateral electrodermal activity (EDA) in these pathological phenomena is at this time poorly understood. Important data for this research represent intracranial stimulation studies which show dominant modulatory influences on EDA originating from ipsilateral limbic structures, where increased stimulation was accompanied by increased EDA response (Mangina Beuzeron-Mangina, 1996). From these data it may be deduced that unilateral or bilateral changes in activity of limbic structures are reflected in ipsilateral changes of EDA and EDA may serve as a window into the limbic system.…”

QEEG Characteristics and Biofeedback Modalities in Children with ADHD

“…The reticular formation controls EDR in connection to states of arousal, the limbic structures (hypothalamus, cingulated gyres and hippocampus) are involved in EDR activity related to emotional responses and thermoregulation, while the motor cortex and parts of the basal ganglia are involved in locomotion. In particular, skin potential and skin conductance used as parameters in EDR biofeedback are related to both sympathetic and parasympathetic arousal (Andreassi 2000;Mangina 1996). …”