Direct hemoperfusion using a polymyxin B immobilized column improves acute respiratory distress syndrome

Abstract

Acute respiratory distress syndrome (ARDS) is characterized by a high mortality rate. We have studied whether direct hemoperfusion using a polymyxin B immobilized fiber column (PMX-DHP) is effective for acute lung injury (ALI) and ARDS. Two ALI and eighteen ARDS patients were evaluated, four congestive heart failure (CHF) patients were evaluated as cardiogenic pulmonary edema, and we retrospectively compared the outcome with ten patients with ARDS who had been hospitalized between 1990 and 1998 as the untreated group. PMX-DHP was carried out twice at a rate of 80-100 ml/minute for 2 hours, with a time interval of approximately 24 hours. We monitored systolic blood pressure (BP), diastolic BP, and the PaO(2)/FIO(2) (PF) ratio before and after PMX-DHP treatment. The mortality was classified if patients were alive at day 30 after initiating PMX-DHP. The mortality of ARDS patients was approximately 20%. Systolic BP increased significantly from 106 +/- 20 to 135 +/- 21 and to 125 +/- 20 mmHg on the following day. Diastolic BP increased from 61 +/- 16 to 78 +/- 15, and to 72 +/- 12 mmHg. The PF ratio increased significantly from 125 +/- 54 to 153 +/- 73, and 163 +/- 78 Torr. CHF patients did not reveal improvement of systolic, diastolic BP, and PF ratio after PMX-DHP. Eight of ten patients in the untreated group died through exacerbated ARDS. In ARDS patients, PMX-DHP improved circulatory disturbance and oxygenation despite the underlying diseases. The mortality improved compared with that before induction of PMX-DHP.

Direct Hemoperfusion Using Polymyxin-B Immobilized Fiber for Septic Shock After Cardiac Surgery

“…PMX-DHP is an effective radical treatment for septic shock. However, although it was reported that PMX-DHP improved lung function in acute lung injury and acute respiratory distress syndrome, 12 and renal function in combination with CHDF in acute renal failure, 13 those effects were not observed in the present study.…”

Two Cases of Acute Exacerbation of Interstitial Pneumonia Treated with Polymyxin B-immobilized Fiber Column Hemoperfusion Treatment

“…However, effective treatments are not well-established and mortality of these patients has been reported to be high during the short course (3, 6, (8)(9)(10)(11). Here, we report two cases of acute exacerbation of IP treated with PMX hemoperfusion treatment.…”

“…Recent reports have suggested that PMX hemoperfusion treatment may be effective in patients with ALI/ARDS and acute exacerbation of IPF (8,9,11). PMX hemoperfusion treatment can reduce the mortality of ARDS (11) …”

Survival from acute exacerbation of idiopathic pulmonary fibrosis with or without direct hemoperfusion with polymyxin B-immobilized fiber column: A retrospective analysis

“…It has been reported that direct hemoperfusion with PMX (PMX-DHP) improves oxygenation in patients with acute lung injury or acute respiratory distress syndrome (ARDS), which usually manifests diffuse alveolar damage (12)(13)(14). In addition, PMX-DHP has also been reported to have a beneficial impact in AE-IPF patients on the respiratory status and long-term outcome (15)(16)(17)(18)(19).…”