Direct hypothalamic innervation of the trigeminal motor nucleus: A retrograde tracer study

McGregor, Ronald L.; Damián, Araceli; Fabbiani, Gabriela; Torterolo, Pablo; Pose, I.; Chase, Michael H.; Morales, Francisco R.

doi:10.1016/j.neuroscience.2005.08.028

Cited by 36 publications

(30 citation statements)

References 32 publications

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“…In addition, unit recordings have revealed non-hypocretinergic neurons that increase their firing rate in conjunction with motor activity (Lee, et al, 2005). Although hypocretinergic neurons seem to be primarily involved in somatomotor activity (Kiyashchenko, et al, 2002, Lee, et al, 2005, Martins, et al, 2004, Mileykovskiy, et al, 2005, Torterolo, et al, 2001, our results suggest that additional, as-yetunidentified neurons in this region may also be involved in this function. The activity of these unidentified neurons decreased during QS, which is in agreement with electrophysiological studies (Alam, et al, 2002).…”

Section: Discussionmentioning

confidence: 49%

“…Although the phenotype of these neurons is unknown, there are several types of candidate neurons present in this region of the hypothalamus. For example, glutamatergic neurons that are present in this area regulate the excitability of hypocretinergic and other local neurons , Ziegler, et al, 2002, and nitrergic neurons of the postero-lateral hypothalamus of the guinea pig project to the hypoglossal and trigeminal motor nuclei (McGregor, et al, 2004, McGregor, et al, 2005. In this regard, we have observed nitrergic cells intermingled with MCHergic and hypocretinergic somata in this region of the cat (unpublished).…”

Section: Discussionmentioning

confidence: 64%

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MCH-containing neurons in the hypothalamus of the cat: Searching for a role in the control of sleep and wakefulness

Torterolo

Sampogna²,

Morales

et al. 2006

Brain Research

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Neurons that utilize melanin-concentrating hormone (MCH) and others that employ hypocretin as neurotransmitter are located in the hypothalamus and project diffusely throughout the CNS, including areas that participate in the generation and maintenance of the states of sleep and wakefulness. In the present report, immunohistochemical methods were employed to examine the distribution of MCHergic and hypocretinergic neurons. In order to test the hypothesis that the MCHergic system is capable of influencing specific behavioral states, we studied Fos immunoreactivity in MCHcontaining neurons during 1) quiet wakefulness, 2) active wakefulness with motor activity, 3) active wakefulness without motor activity, 4) quiet sleep, and, 5) active sleep induced by carbachol (AScarbachol). We determined that MCHergic neuronal somata in the cat are intermingled with hypocretinergic neurons in the dorsal and lateral hypothalamus, principally in the tuberal and tuberomammillary regions; however, hypocretinergic neurons extended more in the anteriorposterior axis than MCHergic neurons. Axosomatic and axodendritic contacts were common between these neurons. In contrast to hypocretinergic neurons, which are known to be active during motor activity and AS-carbachol, Fos immunoreactivity was not observed in MCH-containing neurons in conjunction with any of the preceding behavioral conditions. Non-MCHergic, non-hypocretinergic neurons that expressed c-fos during active wakefulness with motor activity were intermingled with MCH and hypocretin-containing neurons, suggesting that these neurons are related to some aspect of motor function. Further studies are required to elucidate the functional sequela of the interactions between MCHergic and hypocretinergic neurons and the phenotype of the other neurons that were active during motor activity.

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Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 64%

MCH-containing neurons in the hypothalamus of the cat: Searching for a role in the control of sleep and wakefulness

Torterolo

Sampogna²,

Morales

et al. 2006

Brain Research

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“…No particular innervation was noted on the cranial nerve motor nuclei, in contrast to observations made in mammals [Fung et al, 2001;McGregor et al, 2005]. Similarly, the dorsal alar portion of the rhombencephalon in lungfishes is poorly innervated by orexin-ir fibers and the octavolateral nuclei totally lack innervation.…”

Section: Distribution Of Orexin-ir Fibers In the Brain Of Vertebratesmentioning

confidence: 55%

Distribution of Orexin/Hypocretin Immunoreactivity in the Brain of the Lungfishes <i>Protopterus dolloi</i> and <i>Neoceratodus forsteri</i>

et al. 2009

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Lungfishes are currently considered the closest living relatives of tetrapods and represent an interesting group for the study of evolutionary traits in the transition from fishes to tetrapods. The brains of lungfishes have received little attention in comparative studies probably due to the difficulty of obtaining these unique animals. In the present study the distribution of orexin (hypocretin)-like immunoreactivity was studied in the brain of the African lungfish Protopterus dolloi and the Australian lungfish Neoceratodus forsteri by using antibodies directed against the mammalian orexin-A and orexin-B peptides. Simultaneous detection of orexins and tyrosine hydroxylase or serotonin was used to assess the precise location of the orexins in the brain and to evaluate the possible influence of the orexin system on the monoaminergic cell groups. Although some differences were noted, a common pattern for the distribution of orexins in the two lungfishes studied was observed. In both species, most immunoreactive neurons were observed in the suprachiasmatic nucleus and dorsal hypothalamus. Only in Neoceratodus, however, were important cell populations found in the preoptic area and infundibular hypothalamus, whereas small numbers of faintly reactive neurons were present in the lateral septum and ventral striatum. Fiber labeling was widely distributed in all main brain subdivisions, but was more abundant in regions such as the septum, preoptic area, suprachiasmatic nucleus, lateral hypothalamic area, thalamus, pretectum and tegmentum. Less conspicuous was the innervation of the pallial regions, habenula, optic tectum, rhombencephalic reticular formation and spinal cord. Orexinergic innervation was found in close contact with dopaminergic, noradrenergic and serotoninergic cell groups, homologous to the substantia nigra in the midbrain tegmentum, the locus coeruleus, the nucleus of the solitary tract and the raphe nuclei. Although unique features have been found for lungfishes, the location of orexin immunoreactive elements is largely consistent with that recently reported following a similar approach in amphibians and amniotes, suggesting that the general organization of this peptidergic system occurred in the common ancestor of lungfishes and tetrapods.

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“…Of note, orexinergic innervation has been reported in trigeminal and hypoglossal motoneurons of mammals [Fung et al, 2001;McGregor et al, 2005]. In addition, the octavolateral area of holosteans shows a few orexinergic fibers, which is a feature that has been observed in some vertebrates, like cladistians and lungfishes [López et al, 2009a], and in the medial vestibular nucleus of the hamster [Horowitz et al, 2005].…”

Section: Distribution Of Oxir Fibers In the Brain Of Vertebratesmentioning

confidence: 72%

Organization of the Orexin/Hypocretin System in the Brain of Holostean Fishes: Assessment of Possible Relationships with Monoamines and Neuropeptide Y

Lozano

González

López³

2018

Brain Behav Evol

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Holosteans form a small group of actinopterygian fishes considered the sister group of teleosts. Despite this proximity to the biggest group of vertebrates, relatively few studies have been conducted to investigate the organization of the central nervous system of this group of fishes. In this study, the neuroanatomical distribution of orexin/hypocretin-like immunoreactive (OX-ir) cell bodies and fibers was analyzed in the brain of 3 representative species of the 2 orders of extant holosteans, the spotted gar Lepisosteus oculatus, the Florida gar Lepisosteus platyrhincus, and the bowfin Amia calva. Antibodies against orexin-A (OXA) and orexin-B (OXB) were used, which labeled the same cells and fibers throughout the brain. In addition, double immunohistofluorescence was performed for the simultaneous detection of OXA and OXB with tyrosine hydroxylase, serotonin, and neuropeptide Y (NPY), in an attempt to localize the orexinergic structures precisely and study the possible interactions between these neuroactive substances. The pattern of distribution of OX-ir cells in the 3 species was largely similar, showing labeled cells in the preoptic area (POA), and the tuberal and retrotuberal hypothalamic regions, with only subtle differences between species in the density of labeled cells. OX-ir fibers were found in all main brain subdivisions of the 3 species, mostly in the ventral subpallial areas, POA, hypothalamus, posterior tubercle, thalamus, and mesencephalic tectum. Different densities of orexinergic fibers were observed in relation to catecholaminergic and serotoninergic cell groups, as well as an absence of colocalization between orexins and NPY in the same hypothalamic neurons. The comparison of these results with those obtained in other vertebrates highlights a constant pattern of distribution of this system of neurotransmission among different groups of actinopterygian fishes, especially in teleosts. Conserved features shared by all vertebrates studied were also observed, such as the presence of OX-ir cells in the basal hypothalamus, reflecting the preserved functions of these neuropeptides over the course of evolution.

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Direct hypothalamic innervation of the trigeminal motor nucleus: A retrograde tracer study

Cited by 36 publications

References 32 publications

MCH-containing neurons in the hypothalamus of the cat: Searching for a role in the control of sleep and wakefulness

MCH-containing neurons in the hypothalamus of the cat: Searching for a role in the control of sleep and wakefulness

Distribution of Orexin/Hypocretin Immunoreactivity in the Brain of the Lungfishes <i>Protopterus dolloi</i> and <i>Neoceratodus forsteri</i>

Organization of the Orexin/Hypocretin System in the Brain of Holostean Fishes: Assessment of Possible Relationships with Monoamines and Neuropeptide Y

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