Direct Lineage Reprogramming for Induced Keratinocyte Stem Cells: A Potential Approach for Skin Repair

Lin, Haohui; Cai, Sa

doi:10.1093/stcltm/szad019

Cited by 1 publication

(1 citation statement)

References 139 publications

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“…However, the structure and function of the skin can be affected by cuts, burns, surgical incisions or diabetes [3]. The chronic skin wound healing of diabetic patients becomes a challenging problem due to their damaged immune function and blood vessels [4,5]. Hydrogels have shown remarkable advantages in wound repair, are easy to make, and can be loaded with drugs, growth factors and other substances [6,7].…”

Section: Introductionmentioning

confidence: 99%

Wound Microenvironment Self-Adjusting Hydrogels with Thermo-Sensitivity for Promoting Diabetic Wound Healing

Li,

Guo,

Wang

et al. 2023

Gels

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The hard-healing chronic wounds of diabetics are still one of the most intractable problems in clinical skin injury repair. Wound microenvironments directly affect wound healing speed, but conventional dressings exhibit limited efficacy in regulating the wound microenvironment and facilitating healing. To address this serious issue, we designed a thermo-sensitive drug-controlled hydrogel with wound self-adjusting effects, consisting of a sodium alginate (SA), Antheraeapernyi silk gland protein (ASGP) and poly(N-isopropylacrylamide) (PNIPAM) for a self-adjusting microenvironment, resulting in an intelligent releasing drug which promotes skin regeneration. PNIPAM has a benign temperature-sensitive effect. The contraction, drugs and water molecules expulsion of hydrogel were generated upon surpassing lower critical solution temperatures, which made the hydrogel system have smart drug release properties. The addition of ASGP further improves the biocompatibility and endows the thermo-sensitive drug-controlled hydrogel with adhesion. Additionally, in vitro assays demonstrate that the thermo-sensitive drug-controlled hydrogels have good biocompatibility, including the ability to promote the adhesion and proliferation of human skin fibroblast cells. This work proposes an approach for smart drug-controlled hydrogels with a thermo response to promote wound healing by self-adjusting the wound microenvironment.

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