Direct liquid introduction micro-liquid chromatography—mass spectrometry coupling

The coupling of gas and liquid chromatography with mass spectrometry

“…Nebulization takes place in a heated desolvation chamber that promotes e †ective and uniform droplet vaporization. The characteristics of several chamber designs have been discussed by Sugnaux et al 50 Maximum Ñow-rates accepted by DLI interfaces are in the range 50È100 ll min~1 and are best suited for micro-and nanobore chromatography (\1 mm i.d. column).50,51 In these cases, sensitivity is in the picogram range for full-scan detection.…”

Liquid chromatographic/mass spectrometric determination of optically active drugs

“…The electron ionization energy was 230 eV at 300-µ emission current with the standard Cl source block maintained at 250 °C. The standard electron focusing magnet ring was removed to allow use of the extended desolvation chamber described previously (18). Full scan acquisition included a scan from m/z 200 to m/z 500.…”

Direct liquid introduction/thermospray interface for liquid chromatography/mass spectrometry

“…The rounded end cap fits snuggly into the extended desolvation chamber described previously (14). If higher eluent flow rates are utilized ranging from 0.5 to 1.0 mL/min the pinhole diaphragm is removed for thermospray LC/MS experiments.…”