Direct programming of human pluripotent stem cells into endothelial progenitors with SOX17 and FGF2

Ream, Michael W.; Randolph, Lauren N.; Jiang, Yuqian; Chang, Yun; Bao, Xiaoping; Lian, Xiaojun Lance

doi:10.1016/j.stemcr.2024.02.006

Stem Cell Reports

2024

DOI: 10.1016/j.stemcr.2024.02.006

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Direct programming of human pluripotent stem cells into endothelial progenitors with SOX17 and FGF2

Michael W. Ream,

Lauren N. Randolph,

Yuqian Jiang

et al.

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Cited by 2 publications

References 43 publications

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Sox17 and Erg synergistically activate endothelial cell fate in reprogramming fibroblasts

Farber,

Takasugi,

Ricketts

et al. 2025

Journal of Molecular and Cellular Cardiology

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Sox17 and Erg synergistically activate endothelial cell fate in reprogramming fibroblasts

Farber,

Takasugi,

Ricketts

et al. 2025

Journal of Molecular and Cellular Cardiology

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The Influence of Markers in the Differentiation Process of Stem Cells Into Endothelial Cells to Support Treatment Testing Experiments

Nurdiyati

2024

JSCRTE

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Research on stem cells, particularly their differentiation into endothelial cells, is highly significant in the field of biomedical science and regenerative therapy. Endothelial cells are crucial for blood vessel formation, wound healing, tissue regeneration, and the treatment of degenerative diseases. Human pluripotent stem cells can differentiate into various cell types, making them valuable for repairing or replacing damaged tissue. This study reviews the role of markers in distinguishing human stem cells into endothelial cells. A comprehensive literature search was conducted, and out of 428 screened articles, only 4 met the inclusion criteria. SOXF proteins were analyzed using scRNA-seq analysis, focusing on their role in enhancing stem cell differentiation. SOX17 was found to significantly increase the percentage of cells expressing CD34+ and Vascular Endothelial Cadherin (VEC), consistent with its known role in endoderm differentiation and endothelial cell specification. SOX17 can override pluripotency signals in human stem cells, triggering their differentiation into endothelial cells. Overexpression of SOX17 in human stem cells resulted in cells with endothelial characteristics, and combining SOX17 with FGF2 enhanced this effect, resulting in more than 90% of cells expressing endothelial stem cell markers (CD34+, VEC+, CD31+). SOXF was applied to prompt stem cell differentiation, with only SOX17 demonstrating notable effectiveness.

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Direct programming of human pluripotent stem cells into endothelial progenitors with SOX17 and FGF2

Cited by 2 publications

References 43 publications

Sox17 and Erg synergistically activate endothelial cell fate in reprogramming fibroblasts

Sox17 and Erg synergistically activate endothelial cell fate in reprogramming fibroblasts

The Influence of Markers in the Differentiation Process of Stem Cells Into Endothelial Cells to Support Treatment Testing Experiments

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