Direct Reductive Coupling of Nitro Compounds for the Synthesis of Advanced Amines

Abstract

Direct reductive coupling of nitro compounds with C-coupling partners is an atom- and step-economical strategy to access polyfunctional advanced amines. Due to the extremely complex process involved in the reduction of nitro compounds and the high reactivity of N,O-intermediates, few reliable methodologies have been reported for the reductive coupling of nitro compounds since the initial studies. To address this significant challenge, numerous endeavors have been devoted to this important area over the past hundred years. In this short review, we summarize recent advances in this domain and discuss the mechanisms of these appealing reductive coupling transformations.1 Introduction2 Reductive Coupling of Nitro Compounds with Organometallic Reagents3 Reductive Coupling of Nitro Compounds with Arylboronic Acids4 Reductive Coupling of Nitro Compounds with Alkenes5 Reductive Coupling of Nitro Compounds with Alkyl/Aryl Halides6 Reductive Coupling of Nitro Compounds with Alcohols and Their Derivatives7 Conclusion