2005
DOI: 10.1016/j.jasms.2004.10.002
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Direct tissue analysis of phospholipids in rat brain using MALDI-TOFMS and MALDI-ion mobility-TOFMS

Abstract: After water, lipids are the most common biomolecules found in the brain (12%). A brief perusal of the physiology, anatomy, and pathophysiology of the brain illustrates the importance of lipids. Recent advances in mass spectrometry have allowed the direct probing of tissues. However, most studies have focused on proteins. In the present work, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) and MALDI-ion mobility (IM)-TOFMS were employed for direct analysis of phospholi… Show more

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Cited by 152 publications
(154 citation statements)
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“…In cylindrical and spherical FAIMS geometries, this causes focusing that keeps ions near the gap median (counteracting diffusion and Coulomb repulsion), 46,49 which greatly improves sensitivity and permits ion trapping at high pressures. 58,59 This effect would become stronger with increasing n because the dependence of E C on E D gets steeper, as follows from eqs (11), (16), (19), and (21). Therefore, HODIMS could also be performed in cylindrical geometries where ion focusing is critical, and enable the operation of atmospheric-pressure ion traps analogous to t-FAIMS.…”
Section: Mechanical Embodimentmentioning
confidence: 98%
See 3 more Smart Citations
“…In cylindrical and spherical FAIMS geometries, this causes focusing that keeps ions near the gap median (counteracting diffusion and Coulomb repulsion), 46,49 which greatly improves sensitivity and permits ion trapping at high pressures. 58,59 This effect would become stronger with increasing n because the dependence of E C on E D gets steeper, as follows from eqs (11), (16), (19), and (21). Therefore, HODIMS could also be performed in cylindrical geometries where ion focusing is critical, and enable the operation of atmospheric-pressure ion traps analogous to t-FAIMS.…”
Section: Mechanical Embodimentmentioning
confidence: 98%
“…Any of these pairs results in: (19) i.e., the separation is independent of K(0), a, and b. By comparison of eqs (11), (16), and (19), the numerical coefficient with the leading term at separation order n equals 4 1 -n : 1/4 for n = 2, 1/16 for n = 3, and 1/64 for n = 4. This trend supports the above postulate of a 1:2:2:2 ratio for waveform segment durations.…”
Section: Fundamental Feasibility Of Higher-order Differential Ion Mobmentioning
confidence: 99%
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“…The detailed sectioning and sections handling methodology was done as previously reported [17]. The sections were collected onto stainless steel MALDI targets and briefly thaw-mounted before storage at Ϫ20°C.…”
Section: Animalsmentioning
confidence: 99%