Directional hippocampal-prefrontal interactions during working memory

Liu, Tiaotiao; Bai, Wei; Xia, Mi; Tian, Xin

doi:10.1016/j.bbr.2017.10.003

Cited by 48 publications

(32 citation statements)

References 34 publications

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“…It also allowed to characterize gerbils’ exploratory behavior during the step-down task, which consisted of suppression of digging and rearing responses, and increments in probing and jumping behavior. The wide range of responses displayed by gerbils during aversive procedures—perhaps beyond that observed in mice or rats—calls for resuming comparative efforts (e.g., Pérez-Acosta et al, 2016 ; Wang et al, 2017 ), and suggests its better potential for translational clinical studies. Of special interest is the probing behavior, which could be interpreted as risk assessment and has not been reported in other rodent species exposed to step-down and similar tasks.…”

Section: Discussionmentioning

confidence: 99%

Assessing Mongolian gerbil emotional behavior: effects of two shock intensities and response-independent shocks during an extended inhibitory-avoidance task

Hurtado-Parrado

González-León

Arias-Higuera

et al. 2017

PeerJ

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Despite step-down inhibitory avoidance procedures that have been widely implemented in rats and mice to study learning and emotion phenomena, performance of other species in these tasks has received less attention. The case of the Mongolian gerbil is of relevance considering the discrepancies in the parameters of the step-down protocols implemented, especially the wide range of foot-shock intensities (i.e., 0.4–4.0 mA), and the lack of information on long-term performance, extinction effects, and behavioral patterning during these tasks. Experiment 1 aimed to (a) characterize gerbils’ acquisition, extinction, and steady-state performance during a multisession (i.e., extended) step-down protocol adapted for implementation in a commercially-available behavioral package (Video Fear Conditioning System—MED Associates Fairfax, VT, USA), and (b) compare gerbils’ performance in this task with two shock intensities – 0.5 vs. 1.0 mA—considered in the low-to-mid range. Results indicated that the 1.0 mA protocol produced more reliable and clear evidence of avoidance learning, extinction, and reacquisition in terms of increments in freezing and on-platform time as well as suppression of platform descent. Experiment 2 aimed to (a) assess whether an alternate protocol consisting of a random delivery of foot shocks could replicate the effects of Experiment 1 and (b) characterize gerbils’ exploratory behavior during the step-down task (jumping, digging, rearing, and probing). Random shocks did not reproduce the effects observed with the first protocol. The data also indicated that a change from random to response-dependent shocks affects (a) the length of each visit to the platform, but not the frequency of platform descends or freezing time, and (b) the patterns of exploratory behavior, namely, suppression of digging and rearing, as well as increments in probing and jumping. Overall, the study demonstrated the feasibility of the extended step-down protocol for studying steady performance, extinction, and reacquisition of avoidance behavior in gerbils, which could be easily implemented in a commercially available system. The observation that 1.0 mA shocks produced a clear and consistent avoidance behavior suggests that implementation of higher intensities is unnecessary for reproducing aversive-conditioning effects in this species. The observed patterning of freezing, platform descents, and exploratory responses produced by the change from random to periodic shocks may relate to the active defensive system of the gerbil. Of special interest is the probing behavior, which could be interpreted as risk assessment and has not been reported in other rodent species exposed to step-down and similar tasks.

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Section: Discussionmentioning

confidence: 99%

Assessing Mongolian gerbil emotional behavior: effects of two shock intensities and response-independent shocks during an extended inhibitory-avoidance task

Hurtado-Parrado

González-León

Arias-Higuera

et al. 2017

PeerJ

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“…That working memory is disrupted by adolescent 9 -THC supports the hypothesis that adolescent 9 -THC may affect developing MD-mPFC pathways. The hippocampus is involved in numerous behaviors such as social recognition memory (38) and spatial working memory (18). Chronic cannabinoid treatment not only induces dysfunction of prefrontal cortical network activity, but it also disrupts interactions between CA1 and the mPFC (17).…”

Section: The Impact Of Cannabis Use and The Affected Neurotransmittermentioning

confidence: 99%

“…These cognition-related behaviors involve several brain regions, most notably the hippocampus and medial prefrontal cortex (mPFC). Using a Y-maze and rats, the lag of local field potentials between the ventral hippocampus and mPFC indicated that a strong input from the ventral hippocampus to mPFC preceded the correct choice during a working memory task (18). Interestingly, directly applying CP-55940 decreased local field potential oscillations in CA1 and mPFC, also disrupting decisionmaking demonstrating cannabinoid modulation of the ventral hippocampus to mPFC pathway, suggesting it may be susceptible to chronic 9 -THC treatment (17).…”

Section: Introductionmentioning

confidence: 99%

Adolescent Δ9-Tetrahydrocannabinol Exposure Selectively Impairs Working Memory but Not Several Other mPFC-Mediated Behaviors

Chen

2020

Front. Psychiatry

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As the frequency of cannabis use by 14–16-year-olds increases, it becomes increasingly important to understand the effect of cannabis on the developing central nervous system. Using mice as a model system, we treated adolescent (28 day old) C57BL6/J mice of both sexes for 3 weeks with 3 mg/kg tetrahydrocannabinol (THC). Starting a week after the last treatment, several cognitive behaviors were analyzed. Mice treated with THC as adolescents acquired proficiency in a working memory task more slowly than vehicle-treated mice. Working memory recall in both sexes of THC-treated mice was also deficient during increasing cognitive load compared to vehicle-treated mice. Our adolescent THC treatment did not strongly affect social preference, anxiety behaviors, or decision-making behaviors on the elevated T maze task. In summary, under the conditions of this study, adolescent THC treatment of mice markedly affected the establishment, and persistence of working memory, while having little effect on decision-making, social preference or anxiety behaviors. This study provides further support that adolescent THC affects specific behavioral domains.

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“…The researchers believe that both Hp and PFC participate in a distributed neural network to interact with each other to realize the real-time dynamic routing planning and navigation, in which PFC cells provide a coarse encoding of goal location, while Hp place cells represent the geometry of the current environment and the identification of a goal location, providing more elaborate encoding for the rat to plan accurate trajectories in space [ 74 , 75 ]. Based on Hp-PFC theta oscillation synchronization in a spatial cognitive task, the Hp-PFC interactions were further explored and the results indicated that the modulation of Hp activity to PFC is helpful to the successful execution of spatial working memory [ 76 ]. A series of recent studies have also highlighted the Hp-PFC coordination mechanism in spatial working memory tasks.…”

Section: The Role Of Hp-ncl Local Network In Goal-directed Route Imentioning

confidence: 99%

The Role of Hp-NCL Network in Goal-Directed Routing Information Encoding of Bird: A Review

Shang

Zhao

et al. 2020

Brain Sciences

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Goal-directed navigation is a crucial behavior for the survival of animals, especially for the birds having extraordinary spatial navigation ability. In the studies of the neural mechanism of the goal-directed behavior, especially involving the information encoding mechanism of the route, the hippocampus (Hp) and nidopallium caudalle (NCL) of the avian brain are the famous regions that play important roles. Therefore, they have been widely concerned and a series of studies surrounding them have increased our understandings of the navigation mechanism of birds in recent years. In this paper, we focus on the studies of the information encoding mechanism of the route in the avian goal-directed behavior. We first summarize and introduce the related studies on the role of the Hp and NCL for goal-directed behavior comprehensively. Furthermore, we review the related cooperative interaction studies about the Hp-NCL local network and other relevant brain regions supporting the goal-directed routing information encoding. Finally, we summarize the current situation and prospect the existing important questions in this field. We hope this paper can spark fresh thinking for the following research on routing information encoding mechanism of birds.

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Directional hippocampal-prefrontal interactions during working memory

Cited by 48 publications

References 34 publications

Assessing Mongolian gerbil emotional behavior: effects of two shock intensities and response-independent shocks during an extended inhibitory-avoidance task

Assessing Mongolian gerbil emotional behavior: effects of two shock intensities and response-independent shocks during an extended inhibitory-avoidance task

Adolescent Δ9-Tetrahydrocannabinol Exposure Selectively Impairs Working Memory but Not Several Other mPFC-Mediated Behaviors

The Role of Hp-NCL Network in Goal-Directed Routing Information Encoding of Bird: A Review

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