Dirofilaria Immitis

Gj, Weil; Kg, Powers; El, Parbuoni; Br, Line; Rd, Furrow; Ea, Ottesen

doi:10.4269/ajtmh.1982.31.477

Cited by 29 publications

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“…While the experiments of Weil et al (1982) are not directly comparable with ours the short-term scans show that labelled mff accumulate first in the lungs and then in the liver, spleen and kidney; when the mff are impaired the major uptake is by the lungs. The uptake of 51 Cr and 203 Hg by the kidneys and liver at longer term intervals suggests difficulty in using either radio-isotopes for long-term studies when the parasite normally resides in these organs.…”

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confidence: 79%

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External monitoring of ²⁰³Hg-labelled Dirofilaria immitis microfilariae in mice and dogs

et al. 1986

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Microfilariae of Dirofilaria immitis were labelled with 203Hg2+ in vitro and injected into irradiated mice and Beagle dogs. With irradiated mice it was possible to demonstrate microfilariae present in the blood and to detect 203Hg by external counting as long as 28 days after dosing. The 203Hg2+ label had a half-time of 4-5 days; the amount of stable mercury in the labelling medium strongly influenced the survival of microfilariae in vivo. In dogs, external counting showed the lungs to be a major location of the microfilariae soon after reinjection into the host. Evidence was obtained that labelled microfilariae can circulate; however, the detection of dispersed microfilariae is difficult because of the relative insensitivity of the detecting system. For radiomercury the accumulation of the inorganic form in the liver and kidneys limits the long-term usefulness of 203Hg2+ as a label if the organism being studied also accumulates in these organs.

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confidence: 79%

“…At this point it is worthwhile to compare our results with those of Weil et al (1982) who used 51 Cr. Of the two radio-isotopes 203 Hg has the longer half-life; 46 days versus 28 days, and thus may lend itself to longer term studies.…”

Section: Discussionmentioning

confidence: 84%

External monitoring of ²⁰³Hg-labelled Dirofilaria immitis microfilariae in mice and dogs

et al. 1986

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Vaccine Research and Development for the Prevention of Filarial Nematode Infections

Grieve¹,

Wisnewski²,

Frank³

et al. 1995

Vaccine Design

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Immunity toLitomosoides carinii inMastomys natalensis

Zahner

Wegerhof

1986

Z. Parasitenkd.

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Naive Mastomys natalensis, Litomosoides carinii-infected M. natalensis at a postpatent stage of the infection and L. carinii-infected M. natalensis treated chemotherapeutically with furazolidone (FUR), FUR and diethylcarbamazine (FUR/DEC) or amoscanate (AMOS) were challenged by either injection or implantation of 40 third stage larvae (L3, s.c.), 40 fourth stage larvae (L4, 16 days old, i.p.), 20 male and 20 female preadult worms (36 days old, i.p.), 12 adult female worms (i.p.) or 6 X 10(6) microfilariae/kg (i.v.). Microfilaraemia in animals challenged at a postpatent stage (independent of the kind of challenge), was either totally suppressed or at least greatly reduced. Necropsy of L3-challenged animals showed that neither the length of the worms nor their content of morphologically intact, intrauterine stages was affected. Infected, treated animals challenged with developing stages (L3, L4 and preadult worms) showed reduced levels of microfilaraemia (by up to 75%). Dissection of AMOS-treated, L3-challenged animals showed that both the developmental rate and the fertility of the worms were affected. Microfilaraemia was also reduced after implantation of adult worms into treated animals. This was independent of the interval between treatment and challenge (44-150 days) except in animals challenged 10 days after AMOS-treatment, which showed no difference from naive controls. However, infected, treated M. natalensis, cotton rats and gerbils did not develop immunity against intravenously injected blood microfilariae.

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Dirofilaria Immitis

Cited by 29 publications

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External monitoring of ²⁰³Hg-labelled Dirofilaria immitis microfilariae in mice and dogs

External monitoring of ²⁰³Hg-labelled Dirofilaria immitis microfilariae in mice and dogs

Vaccine Research and Development for the Prevention of Filarial Nematode Infections

Immunity toLitomosoides carinii inMastomys natalensis

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Dirofilaria Immitis

Cited by 29 publications

References 0 publications

External monitoring of 203Hg-labelled Dirofilaria immitis microfilariae in mice and dogs

External monitoring of 203Hg-labelled Dirofilaria immitis microfilariae in mice and dogs

Vaccine Research and Development for the Prevention of Filarial Nematode Infections

Immunity toLitomosoides carinii inMastomys natalensis

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Product

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External monitoring of ²⁰³Hg-labelled Dirofilaria immitis microfilariae in mice and dogs

External monitoring of ²⁰³Hg-labelled Dirofilaria immitis microfilariae in mice and dogs