Disc Hemorrhages Are Associated With Localized Three-Dimensional Neuroretinal Rim Thickness Progression in Open-Angle Glaucoma

Margeta, Milica A.; Ratanawongphaibul, Kitiya; Tsikata, Edem; Zemplenyi, Michele; Ondeck, Courtney; Kim, Janice; Coleman, Anne L.; Yu, Fei; Boer, Johannes F. de; Chen, Teresa C.

doi:10.1016/j.ajo.2021.06.021

Cited by 3 publications

(4 citation statements)

References 43 publications

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“…In accordance with previous studies, 23–28 the presence of ODH was revealed as a clinical factor associated with rapid RNFL thinning in the current study. In our Cox proportional hazard model, thinner CCT was also a risk factor for RNFL progression (Table 3), which is also in agreement with those of numerous authors that eyes with glaucoma progression have significantly thinner CCT 29,30 .…”

Section: Discussionsupporting

confidence: 93%

Rate of Retinal Nerve Fiber Layer Thinning in Glaucomatous Eyes With Optic Disc and Parapapillary Deep-Layer Microvasculature Loss

Lee,

Sung,

Kim

et al. 2023

Journal of Glaucoma

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Precis: Microvasculature dropout in the parapapillary choroidal layer was a more important biomarker of glaucomatous nerve fiber layer thinning when it presented with deep-layer microvasculature of the optic disc rather than when it presents by itself. Purpose: To characterize open-angle glaucoma (OAG) eyes with optic nerve head (ONH) deep-layer microvasculature dropout (MvD-D) and parapapillary choroidal layer microvasculature dropout (MvD-P) and compare their retinal nerve fiber layer (RNFL) thinning rate. Methods: This study included 122 OAG eyes that underwent ≥5 serial spectral-domain optical coherence tomography (OCT) scans during a mean follow-up of 5.4 years. Swept-source OCT angiography (SS-OCTA) was used to evaluate MvD-P and MvD-D. Subjects were classified into three groups according to the presence of MvD-P and MvD-D: (1) no dropout (n=37); (2) solely MvD-P (n=40), and (3) both MvD-P and MvD-D (n=45). The RNFL thinning rate was compared among the three groups, and the associated factors were assessed by Cox proportional hazard analysis. Results: RNFL thinning rates were highest in the group with both MvD-P and MvD-D, followed by the group with solely MvD-P and finally by the no dropout group (−0.24 vs. −0.65 vs. −1.20 μm/year, P<0.001). Thinner central corneal thickness (hazard ratio [HR]=0.990, P=0.003), presence of disc hemorrhage (HR=1.802, P=0.035), and coexistence of MvD-P and MvD-D (HR=2.941, P<0.001) were the factors associated with RNFL thinning. Conclusions: The coexistence of MvD-P and MvD-D was associated with faster RNFL thinning than MvD-P alone or no dropout, which suggested that observing the optic disc deep microvasculature along with parapapillary choroidal layer using SS-OCTA may be clinically relevant in monitoring glaucoma progression.

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Section: Discussionsupporting

confidence: 93%

Rate of Retinal Nerve Fiber Layer Thinning in Glaucomatous Eyes With Optic Disc and Parapapillary Deep-Layer Microvasculature Loss

Lee,

Sung,

Kim

et al. 2023

Journal of Glaucoma

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“…The no-DH group might have included patients with undetected DHs, considering the short duration of DH [ 39 ]. However, the interval of three months for DH observation in this study is comparable to that adopted in other studies on DHs [ 11 , 14 , 15 , 16 , 17 , 18 , 20 , 22 , 24 , 29 , 32 , 33 , 34 , 36 , 37 , 38 ]. Although we did not examine the association between DH and systemic diseases or drug usage, systemic hypertension [ 19 , 21 ], diabetes [ 19 , 45 ] and use of aspirin [ 45 ] were reported to be significantly associated with DH occurrence.…”

Section: Discussionsupporting

confidence: 82%

“…Regarding structural progression, photographic enlargement of retinal nerve fiber layer (RNFL) defects is closely associated with DH [ 9 ]. Recently, studies using OCT reported faster thinning of the circumpapillary RNFL, neuroretinal rim, macular retinal ganglion cell (RGC), plus the inner plexiform layer (GCIPL), a representative thickness parameter of the macular inner retinal layers, in association with the occurrence of DH at the site of structural changes [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Association between Glaucoma Progression in Macular Ganglion Cell Complex and Disc Hemorrhage: Differences between Superior and Inferior Hemiretinas

Tachibana

Higashide

Nitta

et al. 2023

JCM

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Disc hemorrhage (DH) is often associated with glaucoma progression. A vertically asymmetrical pattern is typical of glaucoma progression, but it remains unclear whether the association between DH and glaucoma progression differs between the superior and inferior hemiretinas. We compared the thickness changes of the macular ganglion cell complex (GCC) in the hemiretinas of normal-tension glaucoma patients with or without DH, as well as between hemiretinas positive and negative for DH, during five years. Both the superior and inferior hemiretinas in the DH-positive group had a more negative GCC thickness slope in association with more DH counts compared to those in the DH-negative group. Conversely, only the inferior hemiretina exhibited a significant relationship between GCC thickness slope and DH counts when hemiretinas positive and negative for DH in the DH-positive group were compared. In the superior hemifield, the slope of the total deviation changes in the DH-positive hemifield of the DH-positive group was more negative compared to that of the DH-negative group. The association between DH and glaucoma progression in the macular GCC may be stronger in the inferior hemiretina, suggesting that more attention should be paid to DH in the inferior disc area as a sign of glaucoma progression.

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“…Геморрагии по краю ДЗН являются значимым симптомом ГНД. Давно доказано, что геморрагии ДЗН сопряжены с более быстрой потерей полей зрения и более выраженным истончением слоя нервных волокон сетчатки и ганглиозного комплекса сетчатки по данным ОКТ, а также истончением нейроретинального ободка [54][55][56][57].…”

Section: геморрагии на дзн как симптом глаукомы нормального давленияunclassified

Normal-Tension Glaucoma: Epidemiology, Pathogenesis, Diagnosis and Treatment. Review. Part 1

Kurysheva,

Kim,

Plieva

et al. 2023

Oftalʹmologiâ

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In the modern world, glaucoma is one of the main causes of irreversible vision loss. Normal tension glaucoma (NTG) constitutes the major proportion of POAG, which is common in Asian populations. NTG is a disease resulted from the interaction of multiple genetic risk factors. But other factors are also important, such as thinning of the scleral lamina cribrosa and a lesion of the transmembrane pressure gradient. Central visual field defects and disc hemorrhage are characteristics finding that is highly associated with the progression of NTG.

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Disc Hemorrhages Are Associated With Localized Three-Dimensional Neuroretinal Rim Thickness Progression in Open-Angle Glaucoma

Cited by 3 publications

References 43 publications

Rate of Retinal Nerve Fiber Layer Thinning in Glaucomatous Eyes With Optic Disc and Parapapillary Deep-Layer Microvasculature Loss

Rate of Retinal Nerve Fiber Layer Thinning in Glaucomatous Eyes With Optic Disc and Parapapillary Deep-Layer Microvasculature Loss

Association between Glaucoma Progression in Macular Ganglion Cell Complex and Disc Hemorrhage: Differences between Superior and Inferior Hemiretinas

Normal-Tension Glaucoma: Epidemiology, Pathogenesis, Diagnosis and Treatment. Review. Part 1

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