2023
DOI: 10.3390/life13071532
|View full text |Cite
|
Sign up to set email alerts
|

Discovering Deleterious Single Nucleotide Polymorphisms of Human AKT1 Oncogene: An In Silico Study

Abstract: Background: AKT1 is a serine/threonine kinase necessary for the mediation of apoptosis, angiogenesis, metabolism, and cell proliferation in both normal and cancerous cells. The mutations in the AKT1 gene have been associated with different types of cancer. Further, the AKT1 gene mutations are also reported to be associated with other diseases such as Proteus syndrome and Cowden syndromes. Hence, this study aims to identify the deleterious AKT1 missense SNPs and predict their effect on the function and structur… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2024
2024
2025
2025

Publication Types

Select...
2
2

Relationship

0
4

Authors

Journals

citations
Cited by 4 publications
(1 citation statement)
references
References 79 publications
0
1
0
Order By: Relevance
“…In hepatocellular carcinoma, HSP90AA1 regulated the abundance of PKM2, promoted cell glycolysis, and inhibited apoptosis 59 . AKT1 plays a key role in various biological processes such as proliferation, metabolism, and apoptosis 60 , 61 . EGFR is implicated in the proliferation, angiogenesis, invasion, metastasis, and apoptosis of tumour cells when overexpressed 62 , 63 .…”
Section: Discussionmentioning
confidence: 99%
“…In hepatocellular carcinoma, HSP90AA1 regulated the abundance of PKM2, promoted cell glycolysis, and inhibited apoptosis 59 . AKT1 plays a key role in various biological processes such as proliferation, metabolism, and apoptosis 60 , 61 . EGFR is implicated in the proliferation, angiogenesis, invasion, metastasis, and apoptosis of tumour cells when overexpressed 62 , 63 .…”
Section: Discussionmentioning
confidence: 99%