“…Other reactions of functionalized dendralenes, especially those associated with higher homologs that are regioselective, are few in number. [2d, 5] Since most published routes to dendralenes involve double cross-couplings from dihalo-and diborylated intermediates (Figure 2, top) [4,6] selective mono-functionalized and unsymmetrical patterns, which are likely to prove more valuable in total synthesis, remain few in number. In this report, therefore, we describe rapid access to both functionalized symmetrical and unsymmetrical [3]-[6]dendralenes from a common allenic precursor, using Pd-catalyzed crosscouplings under micellar catalysis conditions; i.e., in water and typically at ambient temperature (Figure 2, bottom).…”