Discovery and development of pyridalyl

Abstract

To create a novel insecticide for lepidopterous pest control, we started modi cations of known compounds having a dichloropropenyl moiety that were reported to be active against lepidopterous larvae. Although the lead compound showed only weak activity, some breakthroughs in modi cations brought us dramatic improvements in insecticidal activity and lead to the discovery of pyridalyl. Pyridalyl is highly active against various lepidopterous larvae, thrips and dipterous leafminers. In contrast, it is less toxic to a wide range of bene cial organisms. Unique symptoms in insects exposed to pyridalyl suggest that it has a distinctive insecticidal mode of action. Pyridalyl is expected to be useful in IPM and IRM programs in crop productions.

Long-Chain Molecules with Agro-Bioactivities and Their Applications

“…Pyridalyl ( 38) is a highly efficient and low-toxicity insecticide with excellent control efficacy against Lepidoptera and Thysanoptera pests [117]. Due to its unique chemical structure and characteristic insecticidal profile [118], it has no cross-resistance with various currently used insecticides in Plutella xylostella or Heliothis virescens, inferring that it may have a new mechanism of action [119][120][121] (Figure 20).…”

Liquid chromatography–tandem mass spectrometric methods for the determination of spinosad, thiacloprid and pyridalyl in spring onions and estimation of their pre-harvest interval values

“…Pyridalyl is a relatively new insecticide, bearing a phenoxy pyridaloxy chemical moiety, which has only been scarcely studied and reported in literature. Its action focuses on the control of various lepidoptera and thysanoptera in numerous crops and fruits (Sakamoto et al, 2004) and is also effective on pests that have developed resistance to existing insecticides (Saito, Isayama, Sakamoto & Umeda, 2004;Sakamoto, Hirose, Saito & Umeda 2012). Spinosad is a macrocyclic lactonic biopesticide used against many insect pests in various crops and fruits.…”

Qualitative and quantitative determinations of pyridalyl and metabolites in excrement of two representative Lepidoptera pests

“…13,14 In this sense, metabolites of pyridalyl in Lepidoptera pests, as well as their metabolic pathways, would be helpful for nding out the target enzyme. 15,16 Related research has focused more on the physiological and biological safety of pyridalyl. 9,[17][18][19][20] For instance, mammals and insects, e.g.…”