Discovery and structure-activity relationship studies of novel Bcl-2/Mcl-1 dual inhibitors with indole scaffold

New azole derivatives linked to indole/indoline moieties combined with FLC against drug-resistant Candida albicans

“…They exist mostly in the form of alkaloids in nature, and are used widely in medicinal chemistry because of variable biological activities. 21,22 Previously, we found that indole/indoline derivatives linked to ethylenediamine exhibited an excellent antifungal effect on azole-resistant C. albicans. 23 In the present work, we designed new azole derivatives by recombination of fluconazole and indole/ indoline moieties (Scheme 1), and their in vitro antifungal activity against C. albicans was evaluated.…”