Discovery of anthelmintic small molecules in the Medicines for Malaria Venture’s COVID and Global Health Priority Boxes using an infrared-based assay forCaenorhabditis elegansmotility
Yujie Uli Sun,
Lawrence J. Liu,
Conor R. Caffrey
Abstract:BackgroundParasitic nematodes are a public health problem globally, and an economic burden on animal and plant agricultural industries. With their ability to generate drug resistance, new anthelmintic compounds must be constantly sourced.MethodsUsing the free-living nematode,Caenorhabditis elegans,in an infrared-based motility assay, we screened 400 compounds from two open-source, small-molecule collections distributed by the Medicines for Malaria Venture, namely, the COVID Box and Global Health Priority Box. … Show more
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