Discrepancies between Antimullerian Hormone and Follicle Stimulating Hormone in Assisted Reproduction

Hussain, Munawar; Cahill, David J; Akande, Valentine; Gordon, Uma

doi:10.1155/2013/383278

Cited by 15 publications

(17 citation statements)

References 42 publications

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“…The importance of AMH in human reproduction is confirmed by research of Hussain et al, Lehmann et al, Reichmanm et al, and Wdowiak et al, which indicate that the chance for achieving pregnancy grows together with an increase in the level of AMH in the case of treatment by the in vitro fertilization method. The abovementioned studies did not unequivocally show whether FSH or AMH has a greater predictive value in achieving pregnancy [ 10 , 27 , 28 , 29 ]. In this study, women with very high AMH (polycystic ovarian syndrome) and those with lowered levels of this hormone (premature menopause) were excluded.…”

Section: Discussionmentioning

confidence: 99%

Interactions of Cortisol and Prolactin with Other Selected Menstrual Cycle Hormones Affecting the Chances of Conception in Infertile Women

Wdowiak

Raczkiewicz

Janczyk

et al. 2020

IJERPH

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One of the major problems of success in infertility treatment could depend on the understanding how the potential factors may affect the conception. The aim of this study was to evaluate present understanding of such factors or hormonal causes that may induce infertility. We studied the interactions between the two menstrual cycle hormones i.e., cortisol (COR) and prolactin (PRL), along with the ultrasonographic ovulation parameters in a group of N = 205 women with diagnosed infertility. The control group consisted of N = 100 women with confirmed fertility. In both groups, follicle-stimulating hormone (FSH), luteinizing hormone (LH), anti-Müllerian hormone (AMH), thyroid stimulating hormone (TSH), PRL, COR were examined on the third day of the cycle, and estradiol (E2), progesterone (P), and COR were examined during ovulation and 7-days afterwards. In the infertile group, higher levels of PRL and COR were observed than that of in the control group. Cortisol levels at all phases of the menstrual cycle and PRL negatively correlated with E2 secretion during and after ovulation, thus contributed to the attenuation of the ovulatory LH surge. Infertile women who conceived presented with higher levels of E2 during and after ovulation, higher P after ovulation, and thicker endometrium than that of the women who failed to conceive. In conclusion, elevated secretion of COR and PRL in infertile women impairs the menstrual cycle by decreasing the pre-ovulatory LH peak and E2 and postovulatory E2 levels that affect the endometrial growth, and consequently reduce the chances to conceive.

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Section: Discussionmentioning

confidence: 99%

Interactions of Cortisol and Prolactin with Other Selected Menstrual Cycle Hormones Affecting the Chances of Conception in Infertile Women

Wdowiak

Raczkiewicz

Janczyk

et al. 2020

IJERPH

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“…In a recent retrospective study on women undergoing their first IVF/ICSI cycle, however, concordance between AMH and FSH was noted in 57% of women while 43% of women had discordant values. According to these results, authors concluded that both AMH and FSH tests are probably useful to predict ovarian response but since many women have discordant values, it is difficult to counsel patients regarding their true ovarian reserve using one single marker [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

OvAge: a new methodology to quantify ovarian reserve combining clinical, biochemical and 3D-ultrasonographic parameters

et al. 2015

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BackgroundIn the last decade, both endocrine and ultrasound data have been tested to verify their usefulness for assessing ovarian reserve, but the ideal marker does not yet exist. The purpose of this study was to find, if any, a statistical advanced model able to identify a simple, easy to understand and intuitive modality for defining ovarian age by combining clinical, biochemical and 3D-ultrasonographic data.MethodsThis is a population-based observational study. From January 2012 to March 2014, we enrolled 652 healthy fertile women, 29 patients with clinical suspect of premature ovarian insufficiency (POI) and 29 patients with Polycystic Ovary syndrome (PCOS) at the Unit of Obstetrics & Gynecology of Magna Graecia University of Catanzaro (Italy). In all women we measured Anti Müllerian Hormone (AMH), Follicle Stimulating Hormone (FSH), Estradiol (E2), 3D Antral Follicle Count (AFC), ovarian volume, Vascular Index (VI) and Flow Index (FI) between days 1 and 4 of menstrual cycle. We applied the Generalized Linear Models (GzLM) for producing an equation combining these data to provide a ready to use information about women ovarian reserve, here called OvAge. To introduce this new variable, expression of ovarian reserve, we assumed that in healthy fertile women ovarian age is identical to chronological age. ResultsGzLM applied on the healthy fertile controls dataset produced the following equation OvAge = 48.05 - 3.14*AHM + 0.07*FSH - 0.77*AFC - 0.11*FI + 0.25*VI + 0.1*AMH*AFC + 0.02*FSH*AFC. This model showed a high statistical significance for each marker included in the equation. We applied the final equation on POI and PCOS datasets to test its ability of discovering significant deviation from normality and we obtained a mean of predicted ovarian age significantly different from the mean of chronological age in both groups.ConclusionsOvAge is one of the first reliable attempt to create a new method able to identify a simple, easy to understand and intuitive modality for defining ovarian reserve by combining clinical, biochemical and 3D-ultrasonographic data. Although design data prove a statistical high accuracy of the model, we are going to plan a clinical validation of model reliability in predicting reproductive prognosis and distance to menopause.Electronic supplementary materialThe online version of this article (doi:10.1186/s13048-015-0149-z) contains supplementary material, which is available to authorized users.

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“…It was found that women with a single ovary had higher basal follicle stimulating hormone (FSH) when compared with patients with both ovaries, and it was confirmed that higher FSH is an indicator of poor response for IVF protocols. 15 Unfortunately, we could not compare the age range of our patients, but we observed that patients who had their ovariectomy younger in life responded well. There is no comparative data available to confirm the dominance of one ovary over the other, or which is more important for conception.…”

Section: Discussionmentioning

confidence: 85%

Fertility after oophorectomy due to torsion

Al-Turki

2015

SMJ

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Objectives:To investigate the prevalence of infertility in patients who underwent salpingo-oophorectomy due to adnexal torsion (AT).Methods:All adult women admitted to the Teaching Institution of the University of Dammam, Dammam, Saudi Arabia who underwent surgery due to AT between January 2001 and 2010 were included. Complete data was collected from the time of admission to the follow up. The data was entered into the database and analyzed.Results:The data of 26 patients was available for analysis. The mean age (±standard deviation) at presentation was 22.19±4.4 years, and average age at follow up was 34.81±5.75 years. The average delay in presentation was 37.76±47 hours, and the surgery was performed at 45.07±48.57 hours. The right side was involved in 13 (53.8%) of the cases. Fourteen (53.9%) women presented with infertility. Eleven (78.57%) were treated for infertility, and 5 (45.5%) conceived. Patients who were younger at the time of torsion fared better with regard to pregnancy (p<0.03, 95% confidence interval:-6.85; <0.58).Conclusion:Patients who undergo salpingo-oophorectomy for AT have an increased risk of infertility and should be warned of this impending complication.

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Discrepancies between Antimullerian Hormone and Follicle Stimulating Hormone in Assisted Reproduction

Cited by 15 publications

References 42 publications

Interactions of Cortisol and Prolactin with Other Selected Menstrual Cycle Hormones Affecting the Chances of Conception in Infertile Women

Interactions of Cortisol and Prolactin with Other Selected Menstrual Cycle Hormones Affecting the Chances of Conception in Infertile Women

OvAge: a new methodology to quantify ovarian reserve combining clinical, biochemical and 3D-ultrasonographic parameters

Fertility after oophorectomy due to torsion

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