Discrepancy between regional left ventricular regional circumferential strain assessed by MR-tagging and by speckle tracking echocardiography

Abstract

Background: In recent years, myocardial strain imaging has gained an important place for the evaluation of cardiac patients. Global longitudinal strain assessed by speckle tracking echocardiography (STE) is now commonly used but circumferential strain remains less extensively studied. MR-tagging is recognized as the reference method for circumferential strain analysis, however no validation study between regional MR-tagging and regional STE has been performed up to now. Objective:To compare segmental circumferential strain values (Ecc) obtained by speckle tracking and by MR-tagging in patient with normal systolic function in order to define if both methods are interchangeable or not.Patients and methods: patients without significant regional nor global systolic dysfunction (LVEF > 55%) were studied by MR-tagging (n=82) and by STE (n=35). Left ventricular mid-level short axis slice was obtained by both methods and paired data were available in 16 patients. Segmental Ecc values were computed in six equidistant sectors using GE EchoPac software for STE and InTag post processing software for MR-tagging. Results: 1) Comparison between regions:Overall results showed that regional peak Ecc magnitude |Eccpeak| was not uniform with both methods but in an opposite way. MR-tagging demonstrated significantly lower septal |Eccpeak| as compared with postero-lateral |Eccpeak| (-16.5±3.6 vs -23.4±4.4, p<10 -4 ). Conversely, STE showed significantly higher septal |Eccpeak| as compared with postero-lateral |Eccpeak| (-22.3±6.4 vs -13.9±6.2, p<10 -4 ). 2) Comparison between both methods: In the subgroup of patients studied by both methods, septal |Eccpeak| was 29% lower by MR-tagging as compared with STE (-14.9±2.4 vs -20.9±6.5, p<.006) and postero-lateral |Eccpeak| was 39% lower by STE as compared with MR-tagging (-12.9±5.9 vs -21.0±2.9, p<.0003). 3) Intra and interobserver coefficients of variation were homogeneous (in the range 10%-14%) for all sectors with MR-tagging but were dramatically variable with STE (15% to 20% in the anterior-septal region but three times higher, in the range 35%-40%, in the postero-lateral territory). Conclusion:Regional distributions of Ecc is not uniform but opposite results are provided by MR-tagging and by STE. This finding demonstrates that both methods cannot be considered as interchangeable. These conflicting results raise the www.sciedu.ca/jbgc Journal of Biomedical Graphics and Computing, 2013, Vol. 3, No. 4 ISSN 1925-4008 E-ISSN 1925 76 question of the validity of either MR tagging or speckle tracking for the quantification of regional circumferential strain. Some arguments, developed in the discussion would rather let believe that MR-tagging results should be more reliable.

Cardiac magnetic resonance imaging: insights into developmental programming and its consequences for aging

“…This may be due to the inherent sensitivity of echo speckle to noise and/or the relatively poor lateral resolution of the method. 49 CMR also can be used to assess the focal or diffuse expansion of the myocardial extracellular space, which may result from prior infarction, infection, or other causes of tissue composition derangement. Hematocrit (hct) should be gathered on the same day as the MRI examination as it can fluctuate.…”