Discrepant mutational status between naevi and melanomas in naevus-associated melanomas: about mutation-specific immunohistochemistry

NRASQ61R immunohistochemistry detects both NRASQ61R and KRASQ61R mutations in colorectal cancer

“…Furthermore, intratumoural heterogeneous staining of NRASQ61R IHC is common in melanomas. 5,7,8,19,20 Intratumoural heterogeneity resulted from subclonal evolution within the tumour 8,[19][20][21] and existed between primary and metastatic melanomas. 5,7,22 Heterogeneous expression for NRASQ61R IHC was not observed in this study or in the study of follicular carcinomas conducted by Oishi et al 16 Diffuse and homogeneous expression for NRASQ61R IHC supports the concept that the RAS mutation is generally an early molecular aberration in the adenomacarcinoma pathway of CRCs.…”