Discrete Fourier Transform Convoluted Densitometric Peak Responses for the Determination of Methocarbamol in Different Pharmaceutical Mixtures in the Presence of Its Degradation Product

Ragab, Marwa A.A.; Korany, Mohamed A.; Michail, Karim; Issa, A.; Daabees, H.; El-Kafrawy, Dina S.

doi:10.1080/10826076.2013.825857

Cited by 10 publications

(3 citation statements)

References 14 publications

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“…There have been research that used the LC-MS/MS approach to determine IBU from plasma. To determine the amount of IBU in pharmaceutical preparations, analytical studies have been conducted using the high-performance liquid chromatography (HPLC) method [7][8][9], capillary electrophoresis [10], HPTLC [2,11,12], and spectrofluorimetry [13,14]. However, the analysis time in these research are lengthy, and the pre-analytical preparation procedures are timeconsuming.…”

Section: Introductionmentioning

confidence: 99%

Determination of Ibuprofen in Pharmaceutical Preparations by UPLC-MS/MS Method

Koçak

Atila

2022

Türk Doğa Ve Fen Dergisi

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Ibuprofen (IBU) is a non-steroidal anti-inflammatory drug that is extensively prescribed. For the determination of IBU in pharmaceutical formulations, a sensitive, simple, accurate, and rapid ultra-performance liquid chromatography method in combination with tandem triple quadruple mass spectrometry (UPLC-MS/MS) has been used and validated. The chromatographic separation was accomplished using a C18 UPLC column, 95 Å, 2.1 x 50 mm, 1.8 µm, and 0.1 percent formic acid in conjunction with acetonitrile (25:75 v/v. The flow rate was 0.15 ml min-1, with a run duration of 2.0 minutes. The injection volume was 5 μL and the column temperature was held constant at 40 °C.The mass transitions of İbuprofen and IS were m/z 205.1 → 159.0 and 249.9 → 229.1, respectivelty. According to ICH guidelines, the approach was thoroughly verified. The linear range 1-5000 ng mL-1 calibration curve has a strong correlation coefficient (0.9921). Within and between days precision were expressed as relative standard deviation and were lower than 6.24%. This method has been used to determine IBU in both pure form and pharmaceutical formulations with great success.

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Section: Introductionmentioning

confidence: 99%

Determination of Ibuprofen in Pharmaceutical Preparations by UPLC-MS/MS Method

Koçak

Atila

2022

Türk Doğa Ve Fen Dergisi

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“…Korany et al . introduced a combination of chemometric and statistical methods involving the use of Theil's regression method to circumvent outlier data points.…”

Section: Introductionmentioning

confidence: 99%

“…introduced a combination of chemometric and statistical methods involving the use of Theil's regression method to circumvent outlier data points. This approach has been applied in non‐ideal conditions in different chromatographic analyses such as HPTLC and HPLC using external and internal standard methods of regression . Moreover, the weighted regression method was used for treatment of heteroscedastic data of drug analysis in complex matrices such as plasma .…”

Section: Introductionmentioning

confidence: 99%

Least median of squares and iteratively re‐weighted least squares as robust linear regression methods for fluorimetric determination of α‐lipoic acid in capsules in ideal and non‐ideal cases of linearity

et al. 2018

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This study outlines two robust regression approaches, namely least median of squares (LMS) and iteratively re-weighted least squares (IRLS) to investigate their application in instrument analysis of nutraceuticals (that is, fluorescence quenching of merbromin reagent upon lipoic acid addition). These robust regression methods were used to calculate calibration data from the fluorescence quenching reaction (∆F and F-ratio) under ideal or non-ideal linearity conditions. For each condition, data were treated using three regression fittings: Ordinary Least Squares (OLS), LMS and IRLS. Assessment of linearity, limits of detection (LOD) and quantitation (LOQ), accuracy and precision were carefully studied for each condition. LMS and IRLS regression line fittings showed significant improvement in correlation coefficients and all regression parameters for both methods and both conditions. In the ideal linearity condition, the intercept and slope changed insignificantly, but a dramatic change was observed for the non-ideal condition and linearity intercept. Under both linearity conditions, LOD and LOQ values after the robust regression line fitting of data were lower than those obtained before data treatment. The results obtained after statistical treatment indicated that the linearity ranges for drug determination could be expanded to lower limits of quantitation by enhancing the regression equation parameters after data treatment. Analysis results for lipoic acid in capsules, using both fluorimetric methods, treated by parametric OLS and after treatment by robust LMS and IRLS were compared for both linearity conditions.

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Sustainable development and environmental analysis

Hussain¹,

Keçili²

2020

Modern Environmental Analysis Techniques for Pollutants

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Discrete Fourier Transform Convoluted Densitometric Peak Responses for the Determination of Methocarbamol in Different Pharmaceutical Mixtures in the Presence of Its Degradation Product

Cited by 10 publications

References 14 publications

Determination of Ibuprofen in Pharmaceutical Preparations by UPLC-MS/MS Method

Determination of Ibuprofen in Pharmaceutical Preparations by UPLC-MS/MS Method

Least median of squares and iteratively re‐weighted least squares as robust linear regression methods for fluorimetric determination of α‐lipoic acid in capsules in ideal and non‐ideal cases of linearity

Sustainable development and environmental analysis

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