Discriminant analysis. 2. A new index for antitumor activity

Abstract

ABSTRACT. The antitumor activities of t7 nitrogen analogs of 1, 4-benzoquinone, expressed in eight different ways, were subjected to discriminant analysis. Different methods of measuring the effectiveness of antitumor agents give different results. Methods based on dose levels such as the optimum dose or the lethal dose appear to be more useful in classifying compounds as antitumor agents than methods based on the maximum antitumor effect. A new index for antitumor activity involving the maximum antitumor effect, the optimum dose, and the therapeutic index, examined by discdminant analysis with substitutive parameters as discriminatory variables, can give valuable information for the design of new antitumor drugs.