Disease Free Survival of Well Differentiated Thyroid Cancer: 20 years Experience at a tertiary care center in Lebanon

Arabi, Asma; Shoucair, Mahmoud; Abbas, Jaber; Salti, Ibrahim

doi:10.3823/2545

Cited by 2 publications

(4 citation statements)

References 23 publications

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“…For Arab and Middle Eastern populations, this study will serve as a reference observation looking at various factors affecting DTC outcomes on long-term follow-up. A female predominance was noted, endorsing similar observations from Egypt, United Arab Emirates, Lebanon, and Yemen [ 22 , 23 , 24 , 25 ]. The average age of onset for thyroid cancer among Arabs was observed to occur during the third decade of life.…”

Section: Discussionsupporting

confidence: 83%

“…PTC is the predominant histologic subtype similar to worldwide observations acknowledged in iodine-sufficient regions [ 26 ]. For Arab patients, previous studies that examined the significance of gender on DTC survival were divergent [ 22 , 23 , 24 , 25 ]. In fact, some studies found that gender disparity has no effect on DTC survival at all [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

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Long-Term Survival Analysis and Prognostic Factors of Arabic Patients with Differentiated Thyroid Carcinoma: A 20-Year Observational Study at the King Hussein Cancer Center (KHCC) Involving 528 Patients

Al‐Ibraheem

Al-Rasheed

Mashhadani

et al. 2023

Cancers

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DTC accounts for the majority of endocrine tumors. While the incidence of thyroid cancer has been increasing globally over the past few decades, papillary thyroid carcinoma (PTC) generally shows an excellent prognosis, except in cases with aggressive clinicopathological features. This study aimed to assess the 5- and 10-year overall survival (OS) and progression-free survival (PFS) of 528 Arabic patients diagnosed with primary DTC from 1998 to 2021. Additionally, the study aimed to analyze the impact of various factors on both OS and PFS. An univariable survival analysis was conducted using Kaplan–Meier curves. The 5- and 10-year OS for patients with DTC have exceeded 95%. Additionally, PFS showed very good rates (ranging between 96.5 and 85% at 5 and 10 years, respectively). Age, male gender, risk of recurrence, and distant metastasis were identified as the main negative prognostic factors for both OS and PFS, while RAI treatment was found to be a significant factor in improving OS. Moreover, adherence to the King Hussein Cancer Center’s (KHCC) CPG demonstrated significant improvement in PFS. These findings highlight common prognostic factors and favorable outcomes in Arabic patients with DTC treated at a tertiary cancer center using standard of care approaches.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Long-Term Survival Analysis and Prognostic Factors of Arabic Patients with Differentiated Thyroid Carcinoma: A 20-Year Observational Study at the King Hussein Cancer Center (KHCC) Involving 528 Patients

Al‐Ibraheem

Al-Rasheed

Mashhadani

et al. 2023

Cancers

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“…Most patients with vascular involvement have N1b disease, with one in every five reported to have distant metastasis, thereby conferring a poorer prognosis. 13 , 35 A retrospective study conducted by Falvo et al, 36 indicated a high rate of lymph node involvement (20.5% vs. 3.8%) and distant metastasis (12.8% vs. 1.66%) in DTC patients with angiovascular invasion compared to those without invasion.…”

Section: Discussionmentioning

confidence: 99%

“…Conflicting reports exist regarding the association between age and gender with disease outcomes in DTC patients. Hajj Boutros et al, 13 noted that age at presentation (i.e., patients < 45 years old) was an important predictor of DFS. Similarly, Jonklaas et al, 14 reported that DTC prognosis was better among females < 45 years of age compared to their age-matched male counterparts.…”

Section: Discussionmentioning

confidence: 99%

Disease-free Survival of Patients with Differentiated Thyroid Cancer: A Study from a Tertiary Center in Oman

Kunjumohamed¹,

Rawahi²,

Busaidi³

et al. 2021

Oman Med J

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Objectives: As with global trends, the prevalence of differentiated thyroid cancer (DTC) has increased in recent years in Oman. However, to the best of our knowledge, no local studies have yet been published evaluating the prognosis of DTC cases in Oman. This study aimed to assess disease-free survival (DFS) and prognostic factors related to DTC among Omani patients attending a tertiary care center. Methods: This retrospective, observational cohort study was conducted between January 2006 and May 2016 at the National Diabetes and Endocrine Center in Oman. Data related to DFS and prognostic factors were obtained from the electronic medical records of all ≥ 18-year-old patients diagnosed with DTC during the study period. Results: A total of 346 DTC cases were identified. Overall, 82.7% of patients were disease-free at their last follow-up appointment. Univariate analysis indicated that various tumor characteristics including histological subtype (i.e., papillary carcinoma, Hurthle cell cancer, and minimally invasive follicular thyroid carcinoma), lymph node status, number of lymph node metastases, distant metastasis status, and TNM status (primary tumor (T), regional lymph node (N), distant metastasis (M) stage) were strong prognostic factors for DFS (p < 0.050). According to multivariate regression analysis, lymph node status, extrathyroidal extension, and angiovascular invasion were independent predictors of DFS (p < 0.050). Conclusions: The overall prognosis of DTC among Omani patients was excellent. Treatment and follow-up strategies for patients with DTC should be tailored based on the individual’s risk factor profile.

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Disease Free Survival of Well Differentiated Thyroid Cancer: 20 years Experience at a tertiary care center in Lebanon

Cited by 2 publications

References 23 publications

Long-Term Survival Analysis and Prognostic Factors of Arabic Patients with Differentiated Thyroid Carcinoma: A 20-Year Observational Study at the King Hussein Cancer Center (KHCC) Involving 528 Patients

Long-Term Survival Analysis and Prognostic Factors of Arabic Patients with Differentiated Thyroid Carcinoma: A 20-Year Observational Study at the King Hussein Cancer Center (KHCC) Involving 528 Patients

Disease-free Survival of Patients with Differentiated Thyroid Cancer: A Study from a Tertiary Center in Oman

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