Disease Regression in Malignant Melanoma: Spontaneous Resolution or a Result of Treatment With Antioxidants, Green Tea, and Pineapple Cores? A Case Report

Michael, Agnieszka; Hedayati, Bijan; Dalgleish, Angus

doi:10.1177/1534735406298897

Cited by 5 publications

(4 citation statements)

References 8 publications

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“…The increased periductal lymphatic and blood vessel density that we observed around intraductal breast carcinoma with comedonecrosis and high nuclear grade, that are almost as high as their counterparts in invasive breast carcinoma cases, raises the question of whether these are independent markers of worse prognosis. We can speculate that these vascular changes are an indication of regression of previous invasion as is well recognized in cutaneous malignant melanoma and also recently reported in nonmelanoma skin cancers (44)(45)(46)(47)(48) or perhaps indicates that ''IDC with comedonecrosis'' is actually invasive ductal carcinoma producing duct-like neoplastic structures as the lymphatic and blood vascular densities along with the surrounding periductal desmoplastic reaction are similar to that seen in IC of the breast.…”

Section: Discussionsupporting

confidence: 77%

Significance of Periductal Lymphatic and Blood Vascular Densities in Intraductal Carcinoma of the Breast

et al. 2009

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We investigated the significance of periductal lymphatic and blood vascular densities in intraductal carcinomas (IDC) of the breast. Thirty five cases of pure IDC treated by partial or total mastectomy were reviewed. Seven cases with normal breast tissue and 48 cases of invasive breast carcinoma were included as controls. All cases were immunostained with D2-40 and CD31. Positively stained microvessels were counted in densely vascular/lymphatic foci (hot spots) at 400x (=0.17 mm(2)) in the periductal areas. IDC without comedonecrosis showed a mean periductal D2-40 lymphatic microvessel density (LMD) of 5.8 +/- 5 (range 0-18), and a CD31 microvessel density (MD) of 14 +/- 8.9 (range 1-40). IDC with comedonecrosis showed periductal D2-40 LMD of 8.4 +/- 3.8 (range 4-18), and a CD31 MD of 24.3 +/- 7.6 (range 14-40). There was a significant difference between periductal D2-40 LMD and CD31 MD counts in IDC with and without comedonecrosis. There was a positive correlation of periductal D2-40 LMD and CD31 MD counts with high nuclear grade (r = 0.39 and 0.56) of IDC as well as with the presence of comedonecrosis (r = 0.49 and 0.59). Both D2-40 LMD and CD31 MD did not correlate significantly with tumor size, estrogen status, or progesterone status. As IDC with comedonecrosis and/or high nuclear grade has a worse prognosis than IDC without comedonecrosis and/or with low nuclear grade, it appears that lymphatic and blood vascular density evaluated by D2-40 and CD31, respectively, are independent prognostic indicators for patients with IDC of the breast and may be an indicator of early or unrecognized invasion or "regression."

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Section: Discussionsupporting

confidence: 77%

Significance of Periductal Lymphatic and Blood Vascular Densities in Intraductal Carcinoma of the Breast

et al. 2009

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“…Many biochemical systems in the cells prevent the chain reactions of free radicals in the body (Kruidenier et al, 2002). Antioxidants help stymie many oxidation reactions and inhibit or delay damage to cells and tissues (Michael et al, 2007). An imbalance between antioxidants and oxidative stress can damage sensitive biological tissues (Deby et al, 1986).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Effects of Ethanolic Extract of Polypodium Vulgare on Human Malignant Melanoma Cell Line

Tabeshpour

Shakiban

Qobadi

et al. 2023

Asian Pac J Cancer Prev

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Background: Melanoma is a malignant tumor that originates from the skin's melanocytes and has the highest death rate from skin cancer. Developing more efficacious anticancer medications with fewer adverse effects is the key to effective cancer management. Natural products are considered relevant and cost-effective sources of treatment. The plant (Polypodium vulgare) is a small and evergreen fern. One of the most important chemical compounds in the extract of this herb is flavonoids, which are thought to have beneficial effects in the treatment of melanoma through antioxidant properties. Objectives: Due to the limitations of current cancer management and cytotoxic drugs available in the country, the need to study drugs of natural origin has become more prominent. In this regard, the present study aims to investigate the cytotoxic effects of the ethanolic extract of Polypodium vulgare on A375 melanoma cells. Methods: Polypodium vulgare was extracted in 80% ethanol by the maceration. Then, its effects on the cell death of the melanoma cell line A375 compared to the AGO-1522 cell line as control were measured using the MTT-assay technique. The amount of cellular lipid peroxidation was estimated by TBARS assay. The amount of cellular ROS was calculated by fluorescent reagent 2,7-dichlorofluorescein diacetate. Cytochrome c concentration was measured by a cytochrome c immunoassay kit. Results: In this experiment, the anticancer effects of Polypodium vulgare ethanolic extract on human melanoma cell lines were investigated for the first time. Herb extract with a concentration of 0.123 mg/ml significantly increased the death of A375 melanoma cells (p < 0.001), lipid peroxidation (p < 0.01), and reactive oxygen species (ROS) (p < 0.01) and cytochrome c concentration (p < 0.001). Meanwhile, the same amount was ineffective and safe on AGO-1522 normal fibroblast cells. Conclusion: A 0.123 mg/ml concentration of Polypodium vulgare increases apoptosis in melanoma cells. Meanwhile, the same amount was safe on healthy cells. So, it could be considered an effective treatment without side effects in human melanoma.

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“…In a case study, metastatic melanoma regressed in a patient after she had changed to a diet that was rich in anti-oxidants (β-carotene included). This may have been a case of spontaneous regression, but the possibility also existed that it had been as a result of her change in diet [113]. In another case, oral supplementation of a combination of β-carotene with other anti-oxidants ( i.e.…”

Section: Anti-cancer Dietary Components and Phytochemicalsmentioning

confidence: 99%

Review of Natural Compounds for Potential Skin Cancer Treatment

et al. 2014

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Most anti-cancer drugs are derived from natural resources such as marine, microbial and botanical sources. Cutaneous malignant melanoma is the most aggressive form of skin cancer, with a high mortality rate. Various treatments for malignant melanoma are available, but due to the development of multi-drug resistance, current or emerging chemotherapies have a relatively low success rates. This emphasizes the importance of discovering new compounds that are both safe and effective against melanoma. In vitro testing of melanoma cell lines and murine melanoma models offers the opportunity for identifying mechanisms of action of plant derived compounds and extracts. Common anti-melanoma effects of natural compounds include potentiating apoptosis, inhibiting cell proliferation and inhibiting metastasis. There are different mechanisms and pathways responsible for anti-melanoma actions of medicinal compounds such as promotion of caspase activity, inhibition of angiogenesis and inhibition of the effects of tumor promoting proteins such as PI3-K, Bcl-2, STAT3 and MMPs. This review thus aims at providing an overview of anti-cancer compounds, derived from natural sources, that are currently used in cancer chemotherapies, or that have been reported to show anti-melanoma, or anti-skin cancer activities. Phytochemicals that are discussed in this review include flavonoids, carotenoids, terpenoids, vitamins, sulforaphane, some polyphenols and crude plant extracts.

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Disease Regression in Malignant Melanoma: Spontaneous Resolution or a Result of Treatment With Antioxidants, Green Tea, and Pineapple Cores? A Case Report

Cited by 5 publications

References 8 publications

Significance of Periductal Lymphatic and Blood Vascular Densities in Intraductal Carcinoma of the Breast

Significance of Periductal Lymphatic and Blood Vascular Densities in Intraductal Carcinoma of the Breast

Cytotoxic Effects of Ethanolic Extract of Polypodium Vulgare on Human Malignant Melanoma Cell Line

Review of Natural Compounds for Potential Skin Cancer Treatment

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