Disease relapse after segmental resection and free flap reconstruction for mandibular osteoradionecrosis

Abstract

This present study confirms that microvascular free flaps are reliable for treatment of advanced mandibular ORN. Nevertheless, there remains a 55 percent incidence of wound-healing complications. The lack of objective clinical criteria to judge the appropriate amount of mandible resection in patients with ORN remains an unresolved issue that resulted in the development of recurrent ORN in 25 percent of patients. Further investigations are needed to better understand the pathophysiology of ORN to prevent postoperative wound complications and disease recurrence.

Outcomes of microvascular free flap reconstruction for mandibular osteoradionecrosis: A systematic review

“…All analyses were performed with Comprehensive Meta-analysis (version 2.0). Table 1 shows selected characteristics of the identified studies (Ioannides, Fossion et al 1994, Nakatsuka, Harii et al 1996, Curi and Dib 1997, Santamaria, Wei et al 1998, Chang, Oh et al 2001, Celik, Wei et al 2002, Store, Boysen et al 2002, Militsakh, Wallace et al 2005, Bozec, Poissonnet et al 2006, Suh, Blackwell et al 2010, Baumann, Yu et al 2011, Cannady, Dean et al 2011, Chandarana, Chanowski et al 2013, Sawhney and Ducic 2013, Hillerup, Elberg et al 2014. Eight studies examined populations from North America, one from South America, four from Europe and two from Asia.…”

“…Plate exposure (n=3) Store et al (2002) 7 Infection (n=3) Plate exposure n=1 Suh et al (2010) 38 Infection n=7 Fistula n=6 Plate exposure n=17 Table 3 …”

Mandibular reconstruction with vascularised bone flaps: a systematic review over 25 years

“…By contrast, the Serratus anterior and rib accounted for just 63 flaps (8, 67,90,107,108,113,128,107,149,108,226), while the metatarsal accounted for 32 (17) and lateral arm including humerus for just 10 (72, 167). The trend for reporting by donor site is set out in Table 3.…”

Osteocutaneous free flaps for mandibular reconstruction: systematic review of their frequency of use and a preliminary quality of life comparison

“…Two articles described vascularised rib and serratus anterior flaps. 15,16 The total number of articles using each flap is shown in Figure 2. The numbers do not add up to 60 because some articles reported the use of several different free flap types.…”