Disinfection and sterilization: New technologies

Rutala, William A.; Donskey, Curtis J.; Weber, David J.

doi:10.1016/j.ajic.2023.01.004

Cited by 11 publications

(1 citation statement)

References 120 publications

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“…They were then sprayed with 70% molecular grade ethanol to decontaminate their surfaces and left to air-dry, then placed into open sterile plastic petri dishes. The coupons in the petri dishes were then irradiated on each side for 5 min using the sterilizing UV light within the BSC for a more thorough surface decontamination step ( Rudhart et al, 2022 ; Rutala et al, 2023 ). Post UV-irradiation, lids were placed on the petri dishes, which were then labelled and stored for experimental runs.…”

Section: Methodsmentioning

confidence: 99%

Inactivation of SARS CoV-2 on porous and nonporous surfaces by compact portable plasma reactor

Choudhury,

Lednicky,

Loeb

et al. 2024

Front. Bioeng. Biotechnol.

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We report the inactivation of SARS CoV-2 and its surrogate—Human coronavirus OC43 (HCoV-OC43), on representative porous (KN95 mask material) and nonporous materials (aluminum and polycarbonate) using a Compact Portable Plasma Reactor (CPPR). The CPPR is a compact (48 cm3), lightweight, portable and scalable device that forms Dielectric Barrier Discharge which generates ozone using surrounding atmosphere as input gas, eliminating the need of source gas tanks. Iterative CPPR exposure time experiments were performed on inoculated material samples in 3 operating volumes. Minimum CPPR exposure times of 5–15 min resulted in 4–5 log reduction of SARS CoV-2 and its surrogate on representative material samples. Ozone concentration and CPPR energy requirements for virus inactivation are documented. Difference in disinfection requirements in porous and non-porous material samples is discussed along with initial scaling studies using the CPPR in 3 operating volumes. The results of this feasibility study, along with existing literature on ozone and CPPR decontamination, show the potential of the CPPR as a powerful technology to reduce fomite transmission of enveloped respiratory virus-induced infectious diseases such as COVID-19. The CPPR can overcome limitations of high temperatures, long exposure times, bulky equipment, and toxic residuals related to conventional decontamination technologies.

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Section: Methodsmentioning

confidence: 99%