Disorders of Carbohydrate Absorption, Transmembrane Transport and Metabolism

Derks, Terry G J; Lubout, Charlotte M. A.; Woidy, Mathias; Santer, René

doi:10.1007/978-3-030-67727-5_39

Cited by 1 publication

(1 citation statement)

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“…The cell membrane is a thin semi-permeable membrane that plays the function of transmembrane transport of certain substances [ 31 ]. Accordingly, as shown in Figure S6C , the expression level of the genes encoding the chemical components of intrinsic cell membrane was significantly down-regulated at high oxalic acid concentrations, which may hinder the transmembrane transport of substances.…”

Section: Discussionmentioning

confidence: 99%

Transcriptome Analysis Revealed the Mechanism of Inhibition of Saprophytic Growth of Sparassis latifolia by Excessive Oxalic Acid

Qiu

Wang

et al. 2022

Cells

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Sparassis latifolia, a highly valued edible fungus, is a crucial medicinal and food resource owing to its rich active ingredients and pharmacological effects. Excessive oxalic acid secreted on a pine-sawdust-dominated substrate inhibits its mycelial growth, and severely restricts the wider development of its cultivation. However, the mechanism underlying the relationship between oxalic acid and slow mycelial growth remains unclear. The present study reported the transcriptome-based response of S. latifolia induced by different oxalic acid concentrations. In total, 9206 differentially expressed genes were identified through comparisons of three groups; 4587 genes were down-regulated and 5109 were up-regulated. Transcriptome analysis revealed that excessive oxalic acid mainly down-regulates the expression of genes related to carbohydrate utilization pathways, energy metabolism, amino acid metabolism, protein synthesis metabolism, glycan biosynthesis, and signal transduction pathways. Moreover, genes encoding for wood-degrading enzymes were predominantly down-regulated in the mycelia treated with excessive oxalic acid. Taken together, the study results provide a speculative mechanism underlying the inhibition of saprophytic growth by excessive oxalic acid and a foundation for further research on the growth of S. latifolia mycelia.

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Section: Discussionmentioning

confidence: 99%