Disorders of Phagocyte Function

Weston, William L.

doi:10.1001/archderm.1976.01630350063016

Cited by 9 publications

(1 citation statement)

References 67 publications

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“…Normal phagocyte function has several components: random movement (non-directional), chemotaxis (directional), attachment to the organism, ingestion of the organism, activation of the phagocyte, and bacterial killing (Weston 1976). The basic abnormality in chronic granulomatous disease lies in the processes of phagocyte activation and bacterial killing.…”

Section: Discussionmentioning

confidence: 99%

Chronic Granulomatous Disease in an Adult

Burns

Sárkány

1979

J R Soc Med

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Section: Discussionmentioning

confidence: 99%

Chronic Granulomatous Disease in an Adult

Burns

Sárkány

1979

J R Soc Med

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Experimental cutaneous candidiasis in rodents; II. Role of the stratum corneum barrier and serum complement as a mediator of a protective infalmmatory response

Ray¹,

Wuepper²

1978

Archives of Dermatology

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Of six species of Candida applied epicutaneously to rodents, only C albicans and C stellatoidea penetrate the stratum corneum and produce inflammation. The role of the stratum corneum and produce inflammation. The role of the stratum corneum in experimental murine Candida infections was studied, therefore, by intraepidermal injection of blastospores in mice that received a prior injection of staphylococcal epidermolysin. All six species caused accumulation of neutrophils if placed within an intraepidermal cleft in contact with viable epidermis. The role of serum complement in cutaneous candidiasis was also studied in vivo in rodents depleted of complement with cobra venom factor or deficient in the fifth component of complement. These animals failed to develop neutrophilic inflammatory responses to the six Candida species tested in contrast to control animals. Candida albicans, C stellatoidea, and C tropicalis developed extensive hyphal proliferation with invasion of the entire cutis and subcutis in these animals. The stratum corneum provides an effective barrier to some, but not all Candida species. When this barrier is penetrated, complement mediates an acute neutrophilic pustular response that resticts Candida proliferation and prevents deep invasion of tissue.

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Incontinentia pigmenti. Evidence for both neutrophil and lymphocyte dysfunction

Jessen¹

1978

Archives of Dermatology

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A child with incontinentia pigmenti (Bloch-Sultzberger syndrome) had recurrent pneumococcal meningitis and pneumococcal bacteremia with associated subdural hematomas. Immunologic evaluation revealed defective neutrophil chemotaxis with normal neutrophil chemiluminescense. In addition, lymphocytes showed a depressed proliferative response to phytohemagglutinin stimulation. An immunologic defect may prove to be part of this syndrome.

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Disorders of Phagocyte Function

Cited by 9 publications

References 67 publications

Chronic Granulomatous Disease in an Adult

Chronic Granulomatous Disease in an Adult

Experimental cutaneous candidiasis in rodents; II. Role of the stratum corneum barrier and serum complement as a mediator of a protective infalmmatory response

Incontinentia pigmenti. Evidence for both neutrophil and lymphocyte dysfunction

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