Disorders of pigmentation

Weedon, David

doi:10.1016/b978-0-7020-3485-5.00011-5

Cited by 6 publications

(9 citation statements)

References 777 publications

(623 reference statements)

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“…Fontana–Masson stain showed significantly reduced pigment in lesional epidermis, in agreement with results described in previous studies 3,9,10 . It has been reported that the number of melanocytes is usually decreased in the affected skin 3–6 . Although some authors state that the number of melanocytes may be normal 6 or variable 7 .…”

Section: Discussionsupporting

confidence: 91%

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Clinical and histopathological characteristics of pityriasis alba

Kang

et al. 2009

Clinical and Experimental Dermatology

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Section: Discussionsupporting

confidence: 91%

“…Histopathologically, the number of melanocytes has usually been reported to be decreased; 3–6 however, it may be normal 6 or variable 7 . It is sometimes difficult to differentiate PA clinically from other hypopigmented disorders such as naevus depigmentosus (ND) and vitiligo.…”

Section: Introductionmentioning

confidence: 99%

Clinical and histopathological characteristics of pityriasis alba

Kang

et al. 2009

Clinical and Experimental Dermatology

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“…These findings are in accordance with those of Laihsramet al 2 Melanocytic nevi are characterized clinically by flat-to dome shaped, flesh-to dark brown colored, and solitary-to multiple skin lesions. 3 There are two commonest histologic subtypes of melanocytic nevi, i.e. intradermal and compound melanocytic nevi.…”

Section: Discussionmentioning

confidence: 99%

“…It presents as a dome-shaped, protruding, sharply circumscribed, brown-black lesion characterized by "stuck on" appearance, having greasy surface. It can occur on any part of the body except the palm and sole 3,6 with particular predilection for trunk, forehead, and scalp. Microscopically, these are characterized by proliferation of basaloidkeratinocytes, containing scattered keratin-filled invaginations (pseudohorn cysts), and small keratin-filled (horn) cysts; melanin pigmentation is increased in the basal keratinocytes.…”

mentioning

confidence: 99%

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Common Pigmented Skin Lesions

Khan¹,

Asghar²,

Akhund³

et al. 2018

TPMJ

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ABSTRACT… Objectives: The purpose of this study is; firstly, to study the histopathological spectrum of the pigmented skin lesions in the community, to signify that not all pigmented skin lesions are malignant melanomas; secondly, to assess the age-wise distribution of the common pigmented skin lesions; and thirdly, to determine the commonly affected body sites by these pigmented skin lesions. Study Design: Retrospective/Observational study. Setting: Charsada Teaching Hospital affiliated with Jinnah Medical College Peshawar. Period: 100 consecutive cases with clinical diagnosis of pigmented skin lesion, starting in the year 2013. Methods: In this study, 100 consecutive surgical pathology cases with clinical diagnosis of pigmented skin lesion were retrieved from the archives of Charsada Teaching Hospital affiliated with Jinnah Medical College Peshawar. All the specimens were incisional biopsies of skin, fixed in 10% formalin, embedded in paraffin, and stained with Hematoxylin and Eosin stains. Results: On analyzing 100 consecutive pigmented skin lesions (n=100) starting from the year 2013, it was found thatthe large majority of these lesions were benign. The most common pigmented skin lesion was melanocytic nevus. Moreover, majority of pigmented skin lesions were seen in females. Seborrheic keratosis and malignant tumors, like basal cell carcinoma and squamous cell carcinomas, were more commonly seen in males in the 6 th and 7 th decades of life; whereas, dermatofibroma and post-inflammatory pigmentation were more common in females in the 4 th and 5 th decades of life. Overall, the pigmented skin lesions were more common in the 3 rd , 4 th , and 5 th decades of life with peak in the 4 th decade. Skin of face was the most common site affected by melanocytic nevi and malignant epidermal skin tumors. Conclusions: In conclusion, most of the pigmented skin lesions are benign, encountered in the 4 th decade of life, and commonly affect the skin of face. Also, most of the melanocytic nevi are encountered in females, while most of the malignant epidermal neoplasms are encountered in males affecting the skin of face.

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