Disorders of Subcutaneous Tissue in the Newborn

Tender skin nodules in a newborn

“…[8] There is preponderance of granulomatous macrophage around the skin lesion, and they may liberate 1, 25 dihydroxy cholecalciferol. [9] According to the another hypothesis, hypercalcemia is due to excessive bone resorption, which may occur due to elevated levels of prostaglandin E.[10]…”

“…We used prednisolone orally for hypercalcemia because oral or intravenous steroids act by interfering with metabolism of vitamin D by converting it to the active form 1, 25 dihydroxyvitamin D and also inhibit the macrophage production of this metabolite. [10] Though subcutaneous calcitonin can also be used, it was not needed in this case because the hypercalcemia was controlled with steroids. [10] The rarity of case reports from India prompted us to report this case.…”

“…[10] Though subcutaneous calcitonin can also be used, it was not needed in this case because the hypercalcemia was controlled with steroids. [10] The rarity of case reports from India prompted us to report this case. Though our case had significant hypercalcemia, prompt and judicious treatment resulted in complete recovery within a period of 6 months.…”