Dispersion of microemulsion drops in HEMA hydrogel: a potential ophthalmic drug delivery vehicle

Curcumin-loaded colloidal carrier system: formulation optimization, mechanistic insight, ex vivo and in vivo evaluation

“…23,24 However, due to low retention at the site of application by virtue of low viscosity of nanoemulsion system and inconvenient application, it is often converted into a gel form. [25][26][27][28] Hence, in the present study a gel based colloidal carrier system loaded with CR intended to be used as adjunct therapy for the treatment of inflammation related to arthritic disorders was developed and investigated on a Freund's complete adjuvant (FCA)-induced arthritic rat model. A mechanistic insight to the topical targeting potential of nanoemulsion gel (NEG) was investigated through skin dynamic study by differential scanning calorimetry (DSC), FT-IR microscopy and confocal laser scanning microscopy (CLSM) analysis of the treated rat skin.…”

Designing polymeric microparticles for biomedical and industrial applications

“…The system was designed in order to simulate drug-loaded contact lenses. The microparticles were prepared based on triethoxy(octyl)silane, as previously described [113]. By comparing the drug release profiles of the two approaches, the authors concluded that for the studied system, the mathematical model used and the software package used to implement it, could be employed in the design of contact lenses for a therapeutic application [112].…”

Microemulsions - A Brief Introduction

“…The ability to formulate such mixtures with biocompatible ingredients has made possible to use them in biological and health related areas extensively. Hence, microemulsions have found wide application in delivering drugs with different physical and chemical characteristics and different ways of delivering such as, oral delivery of protein drugs (Sarciaux et al, 1995, Ke et al, 2005, Cheng et al, 2008, Kim et al, 2005, ophthalmic (Lv et al, 2005., Gulsen & Chauhan, 2005, transdermal (Kantaria et al, 1999, Kreilgaard et al, 2000, Sintov & Botner 2006, Neubert, 2011, Zhu et al, 2008, amphiphilic drugs (Djordjevic et al, 2004, Oh et al, 2011, internasal (Cho et al, 2012) or other ways (Zhou et al, 2011, Lawrence & Rees, 2000.…”