DisPhaseDB: An integrative database of diseases related variations in liquid–liquid phase separation proteins

Navarro, Alvaro Martin; Orti, Fernando; Martínez‐Pérez, Elizabeth; Simonetti, Franco L.; Iserte, Javier Alonso; Marino‐Buslje, Cristina

doi:10.1016/j.csbj.2022.05.004

Cited by 7 publications

(1 citation statement)

References 62 publications

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“…In recent literature, there are also other databases that focus on the relationship between PS and diseases, including DisPhaseDB [37]. Although PhaSeDis and DisPhaseDB both include information about PS protein and disease relations, there are some differences between the two databases.…”

Section: Discussionmentioning

confidence: 99%

PhaSeDis: A Manually Curated Database of Phase Separation–Disease Associations and Corresponding Small Molecules

Chen,

Tang,

et al. 2024

Preprint

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Biomacromolecules form membraneless organelles through liquid–liquid phase separation in order to regulate the efficiency of particular biochemical reactions. Dysregulation of phase separation might result in pathological condensation or sequestration of biomolecules, leading to diseases. Thus, phase separation and phase separating factors may serve as drug targets for disease treatment. Nevertheless, such associations have not yet been integrated into phase separation related databases. Therefore, based on MloDisDB, a database for membraneless organelle factor–disease association previously developed by our lab, we constructed PhaSeDis, the phase separation–disease association database. Moreover, we included the information of interacting small molecules with low or high-throughput evidence that might serve as potential drugs for phase separation entries. PhaSeDis strives to offer comprehensive descriptions of each entry, elucidating how phase separating factors induce pathological conditions via phase separation and the mechanisms by which small molecules intervene. We believe that PhaSeDis would be very important in the application of phase separation regulation in treating related diseases. PhaSeDis is available at http://mlodis.phasep.pro.

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Section: Discussionmentioning

confidence: 99%