Disposable pipette extraction: A critical review of concepts, applications, and directions

Carasek, Eduardo; Morés, Lucas; Huelsmann, Ricardo Dagnoni

doi:10.1016/j.aca.2021.339383

Cited by 51 publications

(18 citation statements)

References 87 publications

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“…50 μl) [62,63]. PT-μSPE has been especially relevant as a result of the numerous varieties of commercial alternatives available [64] and the high-throughput automated PT-μSPE approaches that have been described [65]. The favored kinetics of dispersive approaches mentioned above have also permitted the development of miniaturized applications of this technique.…”

Section: Micro-solid Phase Extractionmentioning

confidence: 99%

Ultramicroextraction as a miniaturization of the already miniaturized. A step toward nanoextraction and beyond

Azorín

Benedé

Chisvert

2023

J of Separation Science

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Miniaturization of the analytical process has been a widespread trend, and the sample preparation stage is not exempted from this downscaling. Since the introduction of microextraction techniques as miniaturization of classical extraction techniques, they have become one of the strengths in this field. However, some of the original approaches to these techniques did not fully cover all the current principles of Green Analytical Chemistry. For this reason, during the last years, much emphasis has been placed on reducing/eliminating toxic reagents, reducing the amount of the extraction phase, and searching for new greener, and more selective extractant materials. On the other hand, even though high accomplishments have been achieved, the same attention has not always been paid to reducing the amount of sample, which is essential when treating low‐availability samples such as biological samples, or in developing portable devices. In this review, we intend to give the readership an overview of the advances toward further miniaturization of microextraction techniques. Finally, a brief reflection is made on the terminology used, or that should, in our opinion, be used to term these new generation of miniaturized microextraction approaches. To this regard, the term, ‘ultramicroextraction’ is proposed to refer to those approaches beyond microextraction.

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Section: Micro-solid Phase Extractionmentioning

confidence: 99%

Ultramicroextraction as a miniaturization of the already miniaturized. A step toward nanoextraction and beyond

Azorín

Benedé

Chisvert

2023

J of Separation Science

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“…E-mail: alberto.chisvert@uv.es b Department of Chemistry in Pharmaceutical Sciences, Analytical Chemistry, Faculty of Pharmacy, Complutense University of Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain amounts. Among them, the ones that should be mentioned are miniaturized solid phase microextraction (SPME), 7,8 microextraction by packed sorbents (MEPS) 9 and pipette tip-based strategies such as pipette tip solid phase extraction (PT-SPE), 10,11 dispersive pipette tip extraction (DPX) 12,13 and, more recently, magnetic-based pipette tip microextraction. 14 These pipette-tip based approaches have the advantage of being user-friendly, just needing aspirating/dispensing cycles with a (semi)automatic pipette to perform the extraction of the analytes and easily discard the sample for further steps (i.e., washing and desorption).…”

Section: Introductionmentioning

confidence: 99%

Analysis of microsamples by miniaturized magnetic-based pipette tip microextraction: determination of free cortisol in serum and urine from very low birth weight preterm newborns

Grau

Moreno‐Guzmán

Arruza

et al. 2023

Analyst

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“…After sample disposal, either the analyte or the interferents are retained in the solid material. The application of DPX as a sample preparation technique has been demonstrated for a few analytes; however, the number of commercially avail-able extraction phases and the high cost compared to traditional solid-phase cartridges represent a limitation to its applicability in routine analysis [27,40]. Therefore, developing solid phases for application in DPX suggests a promising field, mainly selective sorbents for tailored applications [41].…”

Section: Introductionmentioning

confidence: 99%

A Molecularly Imprinted Polymer-Disposable Pipette Tip Extraction-Capillary Electrophoresis (MISPE-DPX-CE) Method for the Preconcentration and Determination of Scopolamine in Synthetic Urine Samples

et al. 2022

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Alcoholic beverages contaminated with scopolamine (SCP) are often employed for criminal purposes due to their sedative effect. The determination of the residual levels of SCP in body fluids (e.g., urine) can help to track possible victims of induced ingestions. Biological sample analysis usually requires a preconcentration step to enhance their detectability and to provide sample clean-up. Molecularly imprinted polymers (MIPs) in lieu of conventional solid sorbents represent an enhancement of selectivity, due to their specific recognition sites. Additionally, the adaptation of the solid-phase extraction (SPE) cartridge into a disposable pipette tip extraction (DPX) contributes to the miniaturization of the sample preparation step. Herein, an analytical method for the determination of SCP in synthetic urine samples via the integration of molecularly imprinted solid-phase extraction (MISPE) with DPX as a preconcentration step prior to capillary electrophoresis analysis (also known as MISPE-DPX-CE) is presented. The extraction and elution steps were optimized using a factorial design. Using the optimized conditions, a preconcentration factor of 20 was obtained, leading to a working range of 0.5–6 µM with LOD of 0.04 µM and repeatability of 6.4% (n = 7) and adequate recovery values (84 and 101%) The proposed MISPE-DPX-CE approach was successfully applied to selective extraction, preconcentration, and determination of SCP in synthetic urine samples.

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Disposable pipette extraction: A critical review of concepts, applications, and directions

Cited by 51 publications

References 87 publications

Ultramicroextraction as a miniaturization of the already miniaturized. A step toward nanoextraction and beyond

Ultramicroextraction as a miniaturization of the already miniaturized. A step toward nanoextraction and beyond

Analysis of microsamples by miniaturized magnetic-based pipette tip microextraction: determination of free cortisol in serum and urine from very low birth weight preterm newborns

A Molecularly Imprinted Polymer-Disposable Pipette Tip Extraction-Capillary Electrophoresis (MISPE-DPX-CE) Method for the Preconcentration and Determination of Scopolamine in Synthetic Urine Samples

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