2024
DOI: 10.21203/rs.3.rs-4439134/v1
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Dissecting Causal Relationships Between Inflammation-related Proteins, Plasma Metabolites, and Low Back Pain: A Mendelian Randomization Study

Yan Wang,
Hao Lv,
Zhimu Hu
et al.

Abstract: Background We used Mendelian randomization (MR) to investigate the causal relationship between inflammation-associated proteins, LBP , and potential metabolite mediators. Methods Using the aggregated data of genome-wide association studies (GWAS), the causal relationship between inflammatory proteins and LBP was explored by two-way MR Analysis, and potential mediating metabolites were identified by two-step MR. Sensitivity analysis was performed to further verify the robustness of the results Results After pri… Show more

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