2024
DOI: 10.1101/2024.04.01.587565
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Dissecting Reactive Astrocyte Responses: Lineage Tracing and Morphology-based Clustering

Lina M. Delgado-García,
Ana C. Ojalvo-Sanz,
Thabatta K. E. Nakamura
et al.

Abstract: Brain damage triggers diverse cellular and molecular events, with astrocytes playing a crucial role in activating local neuroprotective and reparative signaling within damaged neuronal circuits. Here, we investigated reactive astrocytes using a multidimensional approach to categorize their responses into different subtypes based on morphology using the StarTrack lineage tracer, single-cell imaging reconstruction and multivariate data analysis. Our findings revealed three profiles of reactive astrocyte response… Show more

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